Quantification of thalamic nuclei in patients diagnosed with temporal lobe epilepsy and hippocampal sclerosis.
Purpose: The aim of this study is to investigate the changes in the volume of individual thalamic nuclei in patients with temporal lobe epilepsy (TLE) and hippocampal sclerosis (HS). Methods: We enrolled 80 TLE patients with HS and 40 healthy controls. All of the subjects underwent 3D T1-weighted im...
| Publicado en: | Neuroradiology Vol. 62; no. 2; pp. 185 - 196 |
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| Autores principales: | , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141292369&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141292369 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Feb2020 vid: 62 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 141292369 141292369 141292369 10.1007/s00234-019-02299-6 141292369 ppf: 185 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Quantification of thalamic nuclei in patients diagnosed with temporal lobe epilepsy and hippocampal sclerosis. aug: au: Lee, Ho-Joon Seo, Sol A Park, Kang Min affil: Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea sug: subj: Epilepsy, Temporal Lobe Pathology Thalamus Pathology Hippocampus Pathology Atrophy Hippocampal Sclerosis Human Diagnostic Imaging Methods Imaging, Three-Dimensional Anticonvulsants ab: Purpose: The aim of this study is to investigate the changes in the volume of individual thalamic nuclei in patients with temporal lobe epilepsy (TLE) and hippocampal sclerosis (HS). Methods: We enrolled 80 TLE patients with HS and 40 healthy controls. All of the subjects underwent 3D T1-weighted imaging. The hippocampus subfields and thalamic nuclei were segmented using the FreeSurfer program. We investigated volume changes in thalamic nuclei according to the HS side involved, and types or antiepileptic drug (AED) response compared with healthy controls. Results: Compared with healthy controls, patients with HS showed atrophy of thalamic nuclei involving right and left parafascicular nuclei. In the right HS, the atrophy of the right thalamic nucleus was more prominent than that of the left thalamic nucleus, whereas the reduction in the volume of left thalamic nuclei was more prominent in patients with left HS. The reduction in thalamic nuclear volumes was more prominent in HS type 1 (atrophy of both CA1 and CA4 regions) than in other HS types. The suprageniculate nuclear volumes were significantly increased in patients with drug-controlled epilepsy. Conclusions: Our study demonstrates thalamic nuclear atrophy in TLE patients with HS. In addition, the atrophy of individual thalamic nuclei varied according to the HS side, the HS types, and the AED response. These findings suggest that the role of thalamic nuclei varied in TLE with HS subtypes and displayed varying degrees of vulnerability in the pathology networks associated with the hippocampus. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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