From metabolic connectivity to molecular connectivity: application to dopaminergic pathways.
Introduction: This study aims to reveal the feasibility and potential of molecular connectivity based on neurotransmission in comparison with the metabolic connectivity with an application to dopaminergic pathways. For this purpose, we propose to compare the neurotransmission connectivity findings u...
| Publicado en: | European Journal of Nuclear Medicine & Molecular Imaging Vol. 47; no. 2; pp. 413 - 425 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Feb2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141318837&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141318837 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16197070 NPC jtl: European Journal of Nuclear Medicine & Molecular Imaging issn: 16197070 maglogo: N pubinfo: dt: Feb2020 vid: 47 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 141318837 10.1007/s00259-019-04574-3 141318837 ppf: 413 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: From metabolic connectivity to molecular connectivity: application to dopaminergic pathways. aug: au: Verger, Antoine Horowitz, Tatiana Chawki, Mohammad B. Eusebio, Alexandre Bordonne, Manon Azulay, Jean-Philippe Girard, Nadine Guedj, Eric affil: Department of Nuclear Medicine & Nancyclotep Imaging platform, CHRU Nancy, F-54000, Nancy, France sug: ab: Introduction: This study aims to reveal the feasibility and potential of molecular connectivity based on neurotransmission in comparison with the metabolic connectivity with an application to dopaminergic pathways. For this purpose, we propose to compare the neurotransmission connectivity findings using 123I-FP-CIT SPECT and 18F-FDOPA PET with the metabolic connectivity findings using 18F-FDG PET. Methods: 18F-FDG PET and 123I-FP-CIT SPECT images from 47 subjects and 18F-FDOPA PET images from 177 subjects, who had no neurological or psychiatric disorders, were studied. Interregional correlation analyses were performed at the group level to determine the midbrain's connectivity via glucose metabolic rate using 18F-FDG PET and via dopaminergic binding potential using 123I-FP-CIT SPECT and 18F-FDOPA PET. SPM-T maps of each radiotracer were generated, and masks used to highlight the significant differences obtained among the imaging modalities and targets. Results: The three dopaminergic pathways (i.e., nigrostriatal, mesolimbic, and mesocortical) were identified by 18F-FDG PET (1599 voxels, with a Tmax value of 12.6), 123I-FP-CIT SPECT (1120 voxels, with Tmax value of 5.1), and 18F-FDOPA PET (6054 voxels, with Tmax value of 11.7) for a T voxel threshold of 5.10, 2.80, and 5.10, respectively. Using the same T voxel threshold of 5.10, 18F-FDOPA PET showed more specific findings than 18F-FDG PET with less voxels identified outside these pathways (− 9323 voxels), whereas no significant voxels were obtained with 123I-FP-CIT SPECT at this threshold. Conclusion: The present study illustrates the feasibility and interest in using molecular connectivity with 18F-FDOPA PET for dopaminergic pathways. Such analyses could be applied to specific diseases involving the dopaminergic system. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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