The Psychoactive Surveillance Consortium and Analysis Network (PSCAN): the first year.
Background and aims: The Psychoactive Surveillance Consortium and Analysis Network (PSCAN) is a national network of academic emergency departments (ED), analytical toxicologists and pharmacologists that collects clinical data paired with biological samples to identify and improve treatments of medic...
| Publicado en: | Addiction Vol. 115; no. 2; pp. 270 - 279 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Feb2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141383223&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141383223 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09652140 AIO jtl: Addiction issn: 09652140 maglogo: Y pubinfo: dt: Feb2020 vid: 115 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 141383223 141383223 141383223 10.1111/add.14808 141383223 ppf: 270 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: The Psychoactive Surveillance Consortium and Analysis Network (PSCAN): the first year. aug: au: Monte, Andrew A. Hopkinson, Andrew Saben, Jessica Shelton, Shelby K. Thornton, Stephen Schneir, Aaron Pomerleau, Adam Hendrickson, Robert G. Arens, Ann M. Cole, Jon B. Chenoweth, James Martin, Spencer Adams, Axel Banister, Samuel D. Gerona, Roy R. affil: Department of Emergency Medicine, University of Colorado School of Medicine, Aurora CO, USA sug: subj: Pharmacovigilance Psychotropic Drugs Emergency Service Clinical Information Systems Human Nonexperimental Studies Medical Records Academic Medical Centers Emergency Care United States Child Specimen Handling Chromatography Methods Mass Spectrometry Narcotics Urine Cannabinoids Urine Intubation Acidosis, Respiratory Tissue Banks Child: 6-12 years ab: Background and aims: The Psychoactive Surveillance Consortium and Analysis Network (PSCAN) is a national network of academic emergency departments (ED), analytical toxicologists and pharmacologists that collects clinical data paired with biological samples to identify and improve treatments of medical conditions arising from use of new psychoactive substances (NPS). The aim of this study was to gather clinical data with paired drug identification from NPS users who presented to EDs within PSCAN during its first year (2016–17). Design Observational study involving patient records and biological samples. Setting: Seven academic emergency medical centers across the United States. Participants: ED patients (n = 127) > 8 years of age with possible NPS use who were identified and enrolled in PSCAN by clinical providers or research personnel. Measurements Clinical signs, symptoms and treatments were abstracted from the patients' health records. Biological samples were collected from leftover urine, serum and whole blood. Biological and drug samples, when available, were tested for drugs and drug metabolites via liquid chromatography–quadrupole time‐of‐flight mass spectrometry (LC‐QTOF/MS). Findings Patients in whom synthetic opioids were detected (n = 9) showed higher rates of intubation (four of nine), impaired mental status (four of nine) and respiratory acidosis (five of nine) compared with the rest of the cohort (nine of 118, P‐value < 0.05). Patients in whom synthetic cannabinoid (SC) were found (n = 27) had lower median diastolic blood pressures (70.5 versus 77 mmHg, P = 0.046) compared with the rest of the cohort. In 64 cases of single drug ingestion, benzodiazepines were administered in 25 cases and considered effective by the treating physician in 21 (84%) cases. Conclusions: During its first year of operation, the Psychoactive Surveillance Consortium and Analysis Network captured clinical data on new classes of drugs paired with biological samples over a large geographical area in the United States. Synthetic cannabinoids were the most common new psychoactive drug identified. Synthetic opioids were associated with a high rate of intubation and respiratory acidosis. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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