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Sibling comparisons elucidate the associations between educational attainment polygenic scores and alcohol, nicotine and cannabis.

Background and Aims: The associations between low educational attainment and substance use disorders (SUDs) may be related to a common genetic vulnerability. We aimed to elucidate the associations between polygenic scores for educational attainment and clinical criterion counts for three SUDs (alcoh...

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Published in:Addiction Vol. 115; no. 2; pp. 337 - 347
Main Authors: Salvatore, Jessica E., Barr, Peter B., Stephenson, Mallory, Aliev, Fazil, Kuo, Sally I‐Chun, Su, Jinni, Agrawal, Arpana, Almasy, Laura, Bierut, Laura, Bucholz, Kathleen, Chan, Grace, Edenberg, Howard J., Johnson, Emma C., McCutcheon, Vivia V., Meyers, Jacquelyn L., Schuckit, Marc, Tischfield, Jay, Wetherill, Leah, Dick, Danielle M.
Format: research tables/charts Journal Article
Published: Wiley-Blackwell Feb2020
Online Access:View this record in EBSCOhost
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      dt: Feb2020
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        atl: Sibling comparisons elucidate the associations between educational attainment polygenic scores and alcohol, nicotine and cannabis.
      aug:
        au:
          Salvatore, Jessica E.
          Barr, Peter B.
          Stephenson, Mallory
          Aliev, Fazil
          Kuo, Sally I‐Chun
          Su, Jinni
          Agrawal, Arpana
          Almasy, Laura
          Bierut, Laura
          Bucholz, Kathleen
          Chan, Grace
          Edenberg, Howard J.
          Johnson, Emma C.
          McCutcheon, Vivia V.
          Meyers, Jacquelyn L.
          Schuckit, Marc
          Tischfield, Jay
          Wetherill, Leah
          Dick, Danielle M.
        affil: Department of Psychology, Virginia Commonwealth University, Richmond VA, USA
      sug:
        subj:
          Siblings
          Educational Status
          Substance Use Disorders Familial and Genetic
          Alcohol-Related Disorders Familial and Genetic
          Nicotine
          Cannabis
          Human
          Male
          Female
          Adult
          Middle Age
          Aged
          Aged, 80 and Over
          Comparative Studies
          Genetics
          Observational Methods
          Confounding Variable
          United States
          Descriptive Statistics
          DSM
          Alleles
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Aged: 65+ years
          Aged, 80 & over
          Male
          Female
      ab: Background and Aims: The associations between low educational attainment and substance use disorders (SUDs) may be related to a common genetic vulnerability. We aimed to elucidate the associations between polygenic scores for educational attainment and clinical criterion counts for three SUDs (alcohol, nicotine and cannabis). Design Polygenic association and sibling comparison methods. The latter strengthens inferences in observational research by controlling for confounding factors that differ between families. Setting: Six sites in the United States. Participants: European ancestry participants aged 25 years and older from the Collaborative Study on the Genetics of Alcoholism (COGA). Polygenic association analyses included 5582 (54% female) participants. Sibling comparisons included 3098 (52% female) participants from 1226 sibling groups nested within the overall sample. Measurements Outcomes included criterion counts for DSM‐5 alcohol use disorder (AUDSX), Fagerström nicotine dependence (NDSX) and DSM‐5 cannabis use disorder (CUDSX). We derived polygenic scores for educational attainment (EduYears‐GPS) using summary statistics from a large (> 1 million) genome‐wide association study of educational attainment. Findings In polygenic association analyses, higher EduYears‐GPS predicted lower AUDSX, NDSX and CUDSX [P < 0.01, effect sizes (R2) ranging from 0.30 to 1.84%]. These effects were robust in sibling comparisons, where sibling differences in EduYears‐GPS predicted all three SUDs (P < 0.05, R2 0.13–0.20%). Conclusions: Individuals who carry more alleles associated with educational attainment tend to meet fewer clinical criteria for alcohol, nicotine and cannabis use disorders, and these effects are robust to rigorous controls for potentially confounding factors that differ between families (e.g. socio‐economic status, urban–rural residency and parental education).
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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