Incidence of Adverse Drug Reactions in High-Risk Pregnancy: A Prospective Cohort Study in Obstetric Intensive Care.
Purpose: To estimate the cumulative incidence of adverse drug reactions (ADRs) in women with high-risk pregnancy hospitalized in an obstetric intensive care unit, then to describe the medicines involved and to identify major risk factors. Methods: From June 2016 to December 2017, patients admitted t...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 76; no. 2; pp. 291 - 299 |
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| Autores principales: | , , , , , |
| Formato: | algorithm research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141385815&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141385815 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: Feb2020 vid: 76 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 141385815 141385815 141385815 10.1007/s00228-019-02789-9 141385815 ppf: 291 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Incidence of Adverse Drug Reactions in High-Risk Pregnancy: A Prospective Cohort Study in Obstetric Intensive Care. aug: au: da Costa, Tatiana Xavier de Almeida Pimenta Cunha, Marta Danielle do Vale Bezerra, Priscilla Karilline Azeredo, Francine Johansson Martins, Rand Randall Oliveira, Antonio Gouveia affil: Postgraduate Program in Pharmaceutical Sciences, Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, Brazil sug: subj: Pregnancy, High Risk Adverse Drug Event Epidemiology Adverse Drug Event Risk Factors Obstetric Care Intensive Care Units Risk Assessment Human Pregnancy Female Patient Admission Nonexperimental Studies Prospective Studies Medical Records Algorithms Univariate Statistics Multiple Logistic Regression Young Adult Adult Gestational Age Severity of Illness Magnesium Sulfate Adverse Effects Disorders of Excessive Somnolence Risk Factors Hypotension Risk Factors Blood Pressure Hemoglobins Blood Odds Ratio Body Temperature Adult: 19-44 years Female ab: Purpose: To estimate the cumulative incidence of adverse drug reactions (ADRs) in women with high-risk pregnancy hospitalized in an obstetric intensive care unit, then to describe the medicines involved and to identify major risk factors. Methods: From June 2016 to December 2017, patients admitted to the ICU with high-risk pregnancy were considered eligible in this observational, longitudinal, prospective study. Patients were investigated daily for the occurrence of ADRs through pharmaceutical anamnesis, active search in medical records and questioning of the health team. Suspected ADRs were classified according to Naranjo's algorithm. Written informed consent was obtained from all patients. Univariate and multivariate logistic regression were used to identify risk factors of ADR. Results: The study population consisted of 607 high-risk pregnancies from 851 women admitted to the ICU, of whom 244 admitted for non-obstetric conditions, with an ICU stay less than 24 h or readmitted to the ICU were excluded. The mean age was 27.0 ± 7.5 years-old, mean gestational age was 33.8 ± 6.3 weeks. ADR were observed in 165 women (27.2%). No severe ADR was observed and 29.7% were of moderate severity. The most often implicated medicine was magnesium sulphate (25.2%) with 44.5% of patients administered that substance experiencing ADRs consisting of somnolence (68.6%), absent patellar reflex (21.6%) and hypotension (9.8%). Risk factors of ADR were blood pressure (adjusted odds-ratio (aOR) 1.02), haemoglobin level (aOR 1.21) and body temperature (aOR 0.71). Conclusions: ADRs affect about one third of high-risk pregnancies, mainly due to magnesium sulphate administrations. High blood pressure, lower body temperature, and high haemoglobin concentration on admission were associated with an increased risk of ADR. pubtype: Academic Journal doctype: algorithm research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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