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Investigating the equivalent performance of biparametric compared to multiparametric MRI in detection of clinically significant prostate cancer.

Purpose: PIRADS v2 stipulates that dynamic contrast-enhanced (DCE) imaging be used to categorize diffusion-weighted-imaging (DWI) score 3 (DWI 3) peripheral zone (PZ) lesions as PIRADS score 3 (PIRADS 3; DCE −) or PIRADS 4 (DCE +). It's controversial for the value of DCE in improving clinically sign...

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Published in:Abdominal Radiology Vol. 45; no. 2; pp. 547 - 556
Main Authors: Wang, Baojun, Gao, Jie, Zhang, Qing, Zhang, Chengwei, Liu, Guangxiang, Wei, Wang, Huang, Haifeng, Fu, Yao, Li, Danyan, Zhang, Bing, Guo, Hongqian
Format: Journal Article
Published: Springer Nature Feb2020
Online Access:View this record in EBSCOhost
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      jtl: Abdominal Radiology
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      dt: Feb2020
      vid: 45
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s00261-019-02281-z
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        atl: Investigating the equivalent performance of biparametric compared to multiparametric MRI in detection of clinically significant prostate cancer.
      aug:
        au:
          Wang, Baojun
          Gao, Jie
          Zhang, Qing
          Zhang, Chengwei
          Liu, Guangxiang
          Wei, Wang
          Huang, Haifeng
          Fu, Yao
          Li, Danyan
          Zhang, Bing
          Guo, Hongqian
        affil: Department of Urology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute of Urology Nanjing University, 321 Zhongshan Rd, Nanjing, Jiangsu, China
      sug:
      ab: Purpose: PIRADS v2 stipulates that dynamic contrast-enhanced (DCE) imaging be used to categorize diffusion-weighted-imaging (DWI) score 3 (DWI 3) peripheral zone (PZ) lesions as PIRADS score 3 (PIRADS 3; DCE −) or PIRADS 4 (DCE +). It's controversial for the value of DCE in improving clinically significant prostate cancer (csPCa) detection. We aimed to figure out whether DCE improves csPCa detection and explore new available measures to improve csPCa detection. Patients and methods: We retrospectively enrolled 375 patients who underwent mp MRI before MRI/ultrasound (US) fusion-targeted biopsy (TB) with transperineal systematic biopsy (SB). All lesions were classified as DWI 3/DCE −, DWI 3/DCE +, DWI 4/PIRADS 4 lesions. Detection rates of csPCa for each lesion group were analyzed. The diagnostic performance of each approach was analyzed by receiver operating characteristics (ROC) analysis and decision curve analysis. Results: Totally, 109 DWI 3 or DWI 4 single lesions in PZ were analyzed (n = 109). The rates of csPCa detection for Group A, Group B, Group C is 10.3%, 13.9%, 55.9%, respectively (A vs. B, p = 0.625; B vs. C, p < 0.001). ROC analysis and decision curve analysis showed the method of combining Age, PSA Density (PSAD) and the mean apparent diffusion coefficient value (ADCmean) outperforms individual approaches for csPCa detection. Conclusion: For DWI 3 lesions in PZ, DCE sequence has not additional value for improving detection of csPCa. The integration of clinical characteristics and bpMRI parameter improves the detection of csPCa.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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