Polydatin Inhibits Adipose Tissue Inflammation and Ameliorates Lipid Metabolism in High-Fat-Fed Mice.
Polydatin (PD), an active component of Chinese herbs, is reported to have many biological functions, such as cardioprotective actions, anti-inflammatory activities, and antitumor effects. In this study, we investigated the effects of PD on body weight control, glucose and lipid metabolic regulation,...
| Published in: | BioMed Research International pp. 1 - 11 |
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| Main Authors: | , , , , , |
| Format: | pictorial research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
11/15/2019
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141408340&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141408340 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 11/15/2019 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 141408340 141408340 141408340 10.1155/2019/7196535 141408340 ppf: 1 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Polydatin Inhibits Adipose Tissue Inflammation and Ameliorates Lipid Metabolism in High-Fat-Fed Mice. aug: au: Li Zheng Jiayuan Wu Juanfen Mo Li Guo Xiaoyan Wu Yi Bao affil: The Key Laboratory, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314000, China sug: subj: Stilbenes Pharmacodynamics Adipose Tissue Drug Effects Body Weight Drug Effects Blood Glucose Drug Effects Inflammation Mediators Drug Effects Lipids Drug Effects Lipids Metabolism Dietary Fats Adverse Effects Obesity Prevention and Control Animal Studies Mice Models, Biological Obesity Etiology Stilbenes Administration and Dosage Cholesterol Drug Effects Triglycerides Drug Effects Lipoproteins, LDL Drug Effects Lipoproteins, HDL Drug Effects RNA, Messenger Drug Effects Gene Expression Drug Effects Peroxisome Proliferator-Activated Receptors Drug Effects Transcription Factors Drug Effects Adipocytes Drug Effects Cell Differentiation Drug Effects Leptin Drug Effects Food Intake Drug Effects Energy Metabolism Drug Effects Chemokines Drug Effects Tumor Necrosis Factor Drug Effects Inflammation Prevention and Control ab: Polydatin (PD), an active component of Chinese herbs, is reported to have many biological functions, such as cardioprotective actions, anti-inflammatory activities, and antitumor effects. In this study, we investigated the effects of PD on body weight control, glucose and lipid metabolic regulation, and anti-inflammation in a high-fat-diet- (HFD-) induced obese mice model. After treatment of PD (100 mg/kg/d for 4 weeks), HFD mice reduced body weight, retroperitoneal fat mass, and adipose cell sizes; significantly lowered serum total cholesterol triglyceride (TG) and low-density lipoprotein (LDL) levels; and increased high- density lipoprotein (HDL) levels compared with the HFD control mice. Further studies showed that PD downregulated the mRNA and protein expressions of peroxisome proliferator-activated receptor gamma (PPARγ), a transcription factor involving in the regulation of adipocyte differentiation, in the retroperitoneal fat of HFD mice. Additionally, PD significantly upregulated the mRNA and protein expressions of leptin, an adipocyte-derived anorexic hormone that regulates food intake and energy expenditure, in the adipose tissues of HFD mice. Moreover, PD reduced the expression levels of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-α) in the retroperitoneal and epididymal tissues of HFD mice, suggesting that PD prevented adipose tissue inflammation. In conclusion, PD may serve as a pharmaceutic candidate for obesity-related lipid metabolism, anti-inflammation, and body weight loss. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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