In vivo assessment of genotoxicity in buccal cells of children undergoing tooth restoration.
Objectives: Whereas dental materials came in direct or close contact with oral tissue, it is a great concern about the biocompatibility of those materials. This study was performed to evaluate possible DNA damage to buccal cells exposed to dental materials.Methods: This prospective, longitudinal cli...
| Publicado en: | Central European Journal of Public Health Vol. 27; no. 4; pp. 312 - 320 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Central European Journal of Public Health
Dec2019
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141437605&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141437605 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 12107778 DRI jtl: Central European Journal of Public Health issn: 12107778 maglogo: N pubinfo: dt: Dec2019 vid: 27 iid: 4 pid: 11076 pub: Central European Journal of Public Health artinfo: ui: 141437605 141437605 NLM31951691 10.21101/cejph.a5216 NLM31951691 141437605 ppf: 312 ppct: 8 formats: fmt: @attributes: type: P tig: atl: In vivo assessment of genotoxicity in buccal cells of children undergoing tooth restoration. aug: au: Gavić, Lidia Goršeta, Kristina Glavina, Domagoj Željezić, Davor Galić, Nada Tadin, Antonija affil: Study of Dental Medicine, School of Medicine, University of Split, Split, Croatia sug: subj: DNA Mouth Mucosa Composite Resins Adverse Effects Dental Restoration, Permanent Prospective Studies Child Scales Child: 6-12 years ab: Objectives: Whereas dental materials came in direct or close contact with oral tissue, it is a great concern about the biocompatibility of those materials. This study was performed to evaluate possible DNA damage to buccal cells exposed to dental materials.Methods: This prospective, longitudinal clinical study was conducted over a three months period. Class II restorations were placed in 60 young patients with no previous filling using one of three tested dental materials (two glass ionomers; Ketac Molar and Ionofil Molar and one compomer material; Twinky Star). DNA damage was analysed by micronucleus assays, in buccal exfoliated epithelial cells.Results: In patients treated with Ketac Molar, a significant frequency of micronuclei (p = 0.027) and binucleated cells in samples taken 30 days following restoration (p = 0.029) was confirmed. In patients treated with Twinky Star, a statistically significant increase in the number of binucleated cells in samples taken after 7 and 30 days following restoration (p = 0.001 and p < 0.001, respectively) was observed. In all samples collected 90 days after treatment, there was no statistical difference in the number of any cell changes.Conclusion: In this study long-term biocompatibility of tested materials was confirmed. Glass ionomers and compomers are widely used materials in paediatric dentistry, and this study has proved their safety for usage in children. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|