Pulmonary Cryptococcosis: comparison of Cryptococcal antigen detection and radiography in Immunocompetent and Immunocompromised patients.
Background: We compared the cryptococcal antigen detection and imaging findings between immunocompetent and immunocompromised patients in whom pulmonary cryptococcosis had been diagnosed. The aim of our study was to determine whether the patient's immune status and radiography affect the detection o...
| Publicado en: | BMC Infectious Diseases Vol. 20; no. 1; pp. 1 - 7 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
BioMed Central
1/30/2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141474422&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141474422 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14712334 1CHU jtl: BMC Infectious Diseases issn: 14712334 maglogo: N pubinfo: dt: 1/30/2020 vid: 20 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 141474422 141474422 NLM32000709 141474422 10.1186/s12879-020-4818-1 NLM32000709 141474422 ppf: 1 ppct: 6 formats: tig: atl: Pulmonary Cryptococcosis: comparison of Cryptococcal antigen detection and radiography in Immunocompetent and Immunocompromised patients. aug: au: Min, Jingqi Huang, Kunlun Shi, Chanmei Li, Laifu Li, Fuye Zhu, Tao Deng, Huojin affil: Department of Pulmonary and Critical Care Medicine, Zhujiang Hospital, Southern Medical University, 510280, Guangzhou, China sug: subj: Immunocompromised Host Cryptococcosis Immunology Antigens, Fungal Blood Cryptococcosis Lung Diseases, Fungal Cryptococcus Immunology Lung Diseases, Fungal Immunology Immunosuppressive Agents Therapeutic Use Retrospective Design Cryptococcosis Drug Therapy Aged Prospective Studies Immunologic Tests Diagnostic Tests, Routine Methods Young Adult Middle Age Tomography, X-Ray Computed Aged, 80 and Over Male Adolescence Lung Diseases, Fungal Drug Therapy Adult Female Scales Funding Source Human Aged: 65+ years Middle Aged: 45-64 years Aged, 80 & over Adolescent: 13-18 years Adult: 19-44 years Male Female ab: Background: We compared the cryptococcal antigen detection and imaging findings between immunocompetent and immunocompromised patients in whom pulmonary cryptococcosis had been diagnosed. The aim of our study was to determine whether the patient's immune status and radiography affect the detection of cryptococcal antigen.Methods: According to whether they took immunosuppressive drugs or not, seventy and eight adult patients with pulmonary cryptococcosis were divided into two groups: the immunocompetent group and the immunocompromised group. According to the detection of CrAg, each group was divided into the CrAg+ group and the CrAg- group. Then, clinical records, laboratory examinations and computed tomography findings were collected and analyzed.Results: No difference was found in baseline characteristics, clinical symptoms, and laboratory investigations. By comparing CrAg detection in these two groups, it was found that the number of CrAg+ cases in the immunocompetent group was more than that in the immunocompromised group. And in the immunocompetent group, diffuse lesions were more common in CrAg+ group and limited lesions were more frequently observed in CrAg- group.Conclusions: The patient's immune status and radiography would affect the detection of cryptococcal antigen. And serum CrAg could be a useful tool for the diagnosis of pulmonary cryptococcosis in immunocompetent patients with extensive lung involvement. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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