High Helicobacter pylori Bacterial Load and Low Cytokine Expression Levels Are Associated with Nodular Gastropathy.
Background and Aims: Nodular gastropathy (NG) is an inflammatory condition of the gastric mucosa characterized by the endoscopic detection of multiple millimeter protrusions. A strong association between NG and Helicobacter pylori and a possible role of NG as a risk factor for undifferentiated gastr...
| Publicado en: | Digestive Diseases & Sciences Vol. 65; no. 2; pp. 565 - 576 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141511003&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141511003 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01632116 1VP jtl: Digestive Diseases & Sciences issn: 01632116 maglogo: N pubinfo: dt: Feb2020 vid: 65 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 141511003 141511003 NLM31392473 141511003 10.1007/s10620-019-05769-2 NLM31392473 141511003 ppf: 565 ppct: 11 formats: tig: atl: High Helicobacter pylori Bacterial Load and Low Cytokine Expression Levels Are Associated with Nodular Gastropathy. aug: au: Mansilla-Vivar, Rodrigo Serrano, Carolina A. Palma, Camila Vera, Macarena Hernandez, Caroll Pizarro, Margarita Torres, Javiera Harris, Paul R. Fuentes-López, Eduardo Riquelme, Arnoldo Espino, Alberto affil: Department of Gastroenterology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile sug: subj: Colony Count, Microbial Cytokines Helicobacter Infections Microbiology Gastritis Microbiology Gastric Mucosa Microbiology Cytokines Metabolism Diagnostic Imaging Female Endosonography Interleukins Metabolism Endoscopy, Digestive System Interleukins Gastritis Metabolism Bacterial Proteins Interleukin 1 Tumor Necrosis Factor Metabolism Gastritis Case Control Studies Helicobacter Pylori Male RNA Metabolism Helicobacter Infections Metabolism Interleukin 1 Metabolism Tumor Necrosis Factor Gastric Mucosa Pathology Adult Gastric Mucosa Metabolism Gastritis Pathology Reverse Transcriptase Polymerase Chain Reaction Young Adult Helicobacter Infections Pathology Helicobacter Infections Antigens, Bacterial Middle Age Human Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Background and Aims: Nodular gastropathy (NG) is an inflammatory condition of the gastric mucosa characterized by the endoscopic detection of multiple millimeter protrusions. A strong association between NG and Helicobacter pylori and a possible role of NG as a risk factor for undifferentiated gastric cancer have been described. The aim of this study was to characterize the pathogenic and inflammatory profile of patients with NG.Methods: Adult patients referred for upper gastrointestinal endoscopy were prospectively enrolled in this study. H. pylori infection status was determined by rapid urease test. Biopsies were stained with hematoxylin-eosin. Sydney and OLGA scores were used to assess gastritis characteristics and gastric cancer risk. PCR analysis was performed to determine bacterial load and virulence factors CagA (and its EPIYA motifs) and VacA alleles. Finally, gastric mucosa cytokine gene expression (IL-8, IL-1β, and TNF-α) was determined by real-time RT-PCR.Results: Forty-eight patients, mean age of 36 years, were recruited. All NG patients were infected by H. pylori. OLGA score was similar in both groups (NG patients and non-NG patients). NG patients had higher bacterial load in the gastric corpus (p = 0.01) and significantly less pro-inflammatory cytokine levels than non-NG infected patients (p = 0.01).Conclusions: In our study, NG is not associated with preneoplastic lesions. An increase in bacterial load without a concomitant increase in mucosal inflammatory cytokine responses in H. pylori-infected subjects with NG may represent a general dampening of immune responses or an additional mechanism of H. pylori active immune evasion. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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