Image-based lung functional radiotherapy planning for non-small cell lung cancer.
Background: This simulation study assessed the feasibility and impact of incorporating additional information from lung perfusion single-photon emission computed tomography (SPECT) into intensity-modulated radiotherapy planning for the treatment of non-small cell lung cancer (NSCLC).Methods: In this...
| Publicado en: | Strahlentherapie und Onkologie Vol. 196; no. 2; pp. 151 - 159 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Feb2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141513419&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141513419 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01797158 NZE jtl: Strahlentherapie und Onkologie issn: 01797158 maglogo: N pubinfo: dt: Feb2020 vid: 196 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 141513419 141513419 NLM31578598 10.1007/s00066-019-01518-6 NLM31578598 141513419 ppf: 151 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Image-based lung functional radiotherapy planning for non-small cell lung cancer. aug: au: Mounessi, Faegheh S. Eckardt, Jörg Holstein, Arne Ewig, Santiago Könemann, Stefan affil: Strahlentherapie Zentrum Bochum, Bochum, Germany sug: subj: Radiotherapy, Conformal Methods Lung Neoplasms Radiotherapy Radiotherapy, Computer-Assisted Methods Tomography, Emission-Computed, Single-Photon Methods Carcinoma, Non-Small-Cell Lung Radiotherapy Lung Neoplasms Carcinoma, Non-Small-Cell Lung Lung Radiation Effects Lung Clinical Assessment Tools Impact of Events Scale ab: Background: This simulation study assessed the feasibility and impact of incorporating additional information from lung perfusion single-photon emission computed tomography (SPECT) into intensity-modulated radiotherapy planning for the treatment of non-small cell lung cancer (NSCLC).Methods: In this simulation study, data of 13 patients with stage I-III NSCLC previously treated by radio(chemo)therapy were used. The SPECT was fused together with radiotherapy planning CT. Functional lung regions (FL) and non-functional lung regions (nFL) were defined based on SPECT images. Four treatment plans were created for each patient: an IMRT and a VMAT plan with planning CT (anatomical plans), and an IMRT and a VMATplan which integrate the additional information from lung perfusion scintigraphy (function plans). Dosimetric parameters were compared between all plans for PTV parameters and normal tissue preservation, focusing on optimizing the lung volume receiving at least 20 Gy (V20Gy).Results: Compared to anatomical plans, functional IMRT and functional VMAT plans reduced functional lung V20Gy in all cases of local and diffuse hypoperfusion patterns of SPECT defects. Similar results were observed for functional lung V30Gy and median dose to functional lung Dmean, but were not statistically significant in any group. A significant increase in non-functional lung V20Gy resulted in both functional plans. There were no significant differences in conformity or heterogeneity indices or PTV median doses between either pair of anatomical and functional plans.Conclusion: The incorporation of functional imaging for radiotherapy planning in non-small cell lung cancer is feasible and appears to be beneficial in preserving a functional lung in non-small cell lung cancer. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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