Beta-carotene, telomerase activity and Alzheimer's disease in old age subjects.
Purpose: Advancing age represents the strongest risk factor for Alzheimer's disease (AD), and the identification of biomarkers able to define what characterizes physiological aging from AD may represent a potential starting point for novel preventive strategies. Among these biomarkers, telomeres see...
| Publicado en: | European Journal of Nutrition Vol. 59; no. 1; pp. 119 - 127 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141544918&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141544918 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Feb2020 vid: 59 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 141544918 141544918 141544918 10.1007/s00394-019-01892-y 141544918 ppf: 119 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Beta-carotene, telomerase activity and Alzheimer's disease in old age subjects. aug: au: Boccardi, Virginia Arosio, Beatrice Cari, Luigi Bastiani, Patrizia Scamosci, Michela Casati, Martina Ferri, Evelyn Bertagnoli, Laura Ciccone, Simona Rossi, Paolo Dionigi Nocentini, Giuseppe Mecocci, Patrizia affil: Section of Gerontology and Geriatrics, Department of Medicine, Institute of Gerontology and Geriatrics, University of Perugia, Piazzale Gambuli 1, 06132, Perugia, Italy sug: subj: Alzheimer's Disease Diagnosis beta Carotene Blood Telomerase Physiology Biological Markers Aging Human Sex Factors Age Factors Smoking Descriptive Statistics Odds Ratio Confidence Intervals Nutrition Carotenoids Dementia ab: Purpose: Advancing age represents the strongest risk factor for Alzheimer's disease (AD), and the identification of biomarkers able to define what characterizes physiological aging from AD may represent a potential starting point for novel preventive strategies. Among these biomarkers, telomeres seem to be a promising target. Interestingly, high intake of carotenoid-rich food may play a role in protecting telomeres by oxidative stress reduction. Accordingly, low plasma β-carotene concentrations have been found in AD subjects when compared with cognitively healthy subjects. In this study, we aim at investigating the hypothesis that low β-carotene might be associated with markers of accelerated cellular aging, including leucocyte telomere length (LTL) and peripheral mononuclear cell (PBMC) telomerase activity in a cohort of old age subjects. Methods: The study was conducted in 68 old age subjects, 37 AD, and 31 age-matched healthy controls. In all subjects, β-carotene plasma level, LTL and peripheral telomerase activity were measured. Results: In all populations, β-carotene significantly and positively (r = 0.320, p = 0.008) correlated with telomerase activity, independent of gender. A model having telomerase activity levels as the dependent variable, and age, gender, smoking habit, and β-carotene as independent variables, confirmed that β-carotene was independently associated with telomerase activity (β = 0.319, p = 0.012). Subjects affected by AD had significantly lower plasmatic levels of β-carotene (448 ± 66 mg/ml vs 497 ± 59 mg/ml, p = 0.001) and LTL (0.53 ± 0.25 vs 0.69 ± 0.29; p = 0.009) as compared with healthy controls. Β-carotene plasma level was associated with AD diagnosis (OR 0.988; IC95% 0.978–0.997; p = 0.013) independently of age, gender, smoking habit, ApoE genotype, and LTL. Conclusion: Our data show that β-carotene may modulate telomerase activity in old age. Moreover, lower plasma β-carotene levels, correlating with peripheral telomerase activity, are associated with AD diagnosis independent of multiple covariates. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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