Optic nerve sheath diameter asymmetry in healthy subjects and patients with intracranial hypertension.

Background: Ultrasonography of the optic nerve sheath diameter (ONSD) is used for the non-invasive assessment of increased intracranial pressure (ICP). ONSD values are usually obtained by averaging the measurements of the two eyes, but asymmetric ONSD dilation is possible, leading to potentially ina...

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Publicado en:Neurological Sciences Vol. 41; no. 2; pp. 329 - 334
Autores principales: Naldi, Andrea, Provero, Paolo, Vercelli, Alessandro, Bergui, Mauro, Mazzeo, Anna Teresa, Cantello, Roberto, Tondo, Giacomo, Lochner, Piergiorgio
Formato: research tables/charts Journal Article
Publicado: Springer Nature Feb2020
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Feb2020
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      pub: Springer Nature
      place: New York, New York
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        atl: Optic nerve sheath diameter asymmetry in healthy subjects and patients with intracranial hypertension.
      aug:
        au:
          Naldi, Andrea
          Provero, Paolo
          Vercelli, Alessandro
          Bergui, Mauro
          Mazzeo, Anna Teresa
          Cantello, Roberto
          Tondo, Giacomo
          Lochner, Piergiorgio
        affil: Department of Neuroscience "Rita Levi Montalcini", University of Turin, Turin, Italy
      sug:
        subj:
          Optic Nerve Pathology
          Intracranial Pressure Physiology
          Intracranial Hypertension Pathology
          Cerebral Hemorrhage Pathology
          Adult
          Aged
          Research Subjects
          Eye Pathology
          Male
          Middle Age
          Female
          Human
          Adult: 19-44 years
          Aged: 65+ years
          Middle Aged: 45-64 years
          Male
          Female
      ab: Background: Ultrasonography of the optic nerve sheath diameter (ONSD) is used for the non-invasive assessment of increased intracranial pressure (ICP). ONSD values are usually obtained by averaging the measurements of the two eyes, but asymmetric ONSD dilation is possible, leading to potentially inaccurate ICP estimation when using binocular averaging. In addition, few data are available about the asymmetry of the ONSD and the use of the maximum ONSD value between eyes for raised ICP detection. The aim of the study was to evaluate the interocular ONSD asymmetry in healthy subjects and patients with intracranial hypertension (IH) by ultrasonography and to investigate whether the maximum ONSD could be as useful as the binocular assessment.Methods: Forty healthy subjects and 40 patients with IH (20 with idiopathic intracranial hypertension and 20 with intracerebral hemorrhage) who underwent transorbital sonography were retrospectively enrolled. The prevalence and degree of ONSD asymmetry were compared among groups; ONSD median binocular and maximum values were compared.Results: Forty-two out of 80 subjects (52.5%) showed significant ONSD asymmetry, without significant differences in prevalence among groups (p = 0.28). The median asymmetry was higher in patients than in healthy subjects (0.45 mm vs 0.23 mm; p = 0.007), without significant differences between the two pathologies (p = 0.58). Both binocular and maximum ONSD measurements were significantly higher in patients with IH than in controls (p < 0.001).Conclusions: Interocular ONSD asymmetry occurs both in healthy subjects and, more consistently, in patients with IH. Both binocular and maximum ONSD may be useful markers for increased ICP detection.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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