Medial temporal lobe volumes in late-life depression: effects of age and vascular risk factors.
Substantial work associates late-life depression with hippocampal pathology. However, there is less information about differences in hippocampal subfields and other connected temporal lobe regions and how these regions may be influenced by vascular factors. Individuals aged 60 years or older with an...
| Publicado en: | Brain Imaging & Behavior Vol. 14; no. 1; pp. 19 - 30 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Feb2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141624947&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141624947 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Feb2020 vid: 14 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 141624947 141624947 NLM30251182 10.1007/s11682-018-9969-y NLM30251182 141624947 ppf: 19 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Medial temporal lobe volumes in late-life depression: effects of age and vascular risk factors. aug: au: Taylor, Warren D. Deng, Yi Boyd, Brian D. Donahue, Manus J. Albert, Kimberly McHugo, Maureen Gandelman, Jason A Landman, Bennett A. affil: The Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, 1601 23rd Avenue South, 37212, Nashville, TN, USA sug: subj: Depression Physiopathology Temporal Lobe Physiopathology Cerebrovascular Circulation Physiology Depression Metabolism Hippocampus Pathology Atrophy Pathology Magnetic Resonance Imaging Methods Aged, 80 and Over Middle Age Cerebral Cortex Pathology Aged Male Risk Factors Temporal Lobe Metabolism Age Factors Prospective Studies Female Scales Aged, 80 & over Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Substantial work associates late-life depression with hippocampal pathology. However, there is less information about differences in hippocampal subfields and other connected temporal lobe regions and how these regions may be influenced by vascular factors. Individuals aged 60 years or older with and without a DSM-IV diagnosis of Major Depressive Disorder completed clinical assessments and 3 T cranial MRI using a protocol allowing for automated measurement of medial temporal lobe subfield volumes. A subset also completed pseudo-continuous arterial spin labeling, allowing for the measurement of hippocampal cerebral blood flow. In 59 depressed and 21 never-depressed elders (mean age = 66.4 years, SD = 5.8y, range 60-86y), the depressed group did not exhibit statistically significant volumetric differences for the total hippocampus or hippocampal subfields but did exhibit significantly smaller volumes of the perirhinal cortex, specifically in the BA36 region. Additionally, age had a greater effect in the depressed group on volumes of the cornu ammonis, entorhinal cortex, and BA36 region. Finally, both clinical and radiological markers of vascular risk were associated with smaller BA36 volumes, while reduced hippocampal blood flow was associated with smaller hippocampal and cornu ammonis volumes. In conclusion, while we did not observe group differences in hippocampal regions, we observed group differences and an effect of vascular pathology on the BA36 region, part of the perirhinal cortex. This is a critical region exhibiting atrophy in prodromal Alzheimer's disease. Moreover, the observed greater effect of age in the depressed groups is concordant with past longitudinal studies reporting greater hippocampal atrophy in late-life depression. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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