The effect of midlife cardiovascular risk factors on white matter hyperintensity volume and cognition two decades later in normal ageing women.
Cerebral White Matter Hyperintensity (WMH) lesions have been identified as markers of cerebrovascular diseases and they are associated with increased risk of cognitive impairment. In this study, we investigated the relationship between midlife cardiovascular risk factors and late life WMH volumes tw...
| Publicado en: | Brain Imaging & Behavior Vol. 14; no. 1; pp. 51 - 62 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Feb2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141624948&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141624948 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Feb2020 vid: 14 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 141624948 141624948 NLM30259291 10.1007/s11682-018-9970-5 NLM30259291 141624948 ppf: 51 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The effect of midlife cardiovascular risk factors on white matter hyperintensity volume and cognition two decades later in normal ageing women. aug: au: Aljondi, Rowa Szoeke, Cassandra Steward, Chris Gorelik, Alexandra Desmond, Patricia affil: Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Parkville, 3010, Melbourne, VIC, Australia sug: subj: Cognition Pathologic Processes Physiopathology Brain Pathology Neuropsychological Tests Pathologic Processes Cardiovascular Diseases Complications Aging Risk Factors Female Lipoproteins, HDL Cholesterol Analysis Cardiovascular Diseases Lipoproteins, HDL Cholesterol Adverse Effects Brain Aged Middle Age Cognition Disorders Pathology Prospective Studies Magnetic Resonance Imaging Methods Clinical Assessment Tools Impact of Events Scale Aged: 65+ years Middle Aged: 45-64 years Female ab: Cerebral White Matter Hyperintensity (WMH) lesions have been identified as markers of cerebrovascular diseases and they are associated with increased risk of cognitive impairment. In this study, we investigated the relationship between midlife cardiovascular risk factors and late life WMH volumes two decades later, and examined their association with cognitive performance. 135 participants from the Women's Healthy Ageing Project had completed midlife cardiovascular risk measurement in 1992 and late life brain MRI scan and cognitive assessment in 2012. In these community-dwelling normal aging women, we found that higher midlife Framingham Cardiovascular Risk Profile (FCRP) score was associated with greater WMH volume two decades later, and was predominantly driven by the impact of HDL cholesterol level, controlling for age, education and APOE ε4 status. Structural equation modelling demonstrated that the relationship between midlife FCRP score and late life executive function was mediated by WMH volume. These findings suggest intervention strategies that target major cardiovascular risk factors at midlife might be effective in reducing the development of WMH lesions and thus late life cognitive decline. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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