Regional growth trajectories of cortical myelination in adolescents and young adults: longitudinal validation and functional correlates.
Adolescence is a time of continued cognitive and emotional evolution occurring with continuing brain development involving synaptic pruning and cortical myelination. The hypothesis of this study is that heavy myelination occurs in cortical regions with relatively direct, predetermined circuitry supp...
| Publicado en: | Brain Imaging & Behavior Vol. 14; no. 1; pp. 242 - 267 |
|---|---|
| Autores principales: | , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Feb2020
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141624957&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141624957 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Feb2020 vid: 14 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 141624957 141624957 NLM30406353 10.1007/s11682-018-9980-3 NLM30406353 141624957 ppf: 242 ppct: 25 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Regional growth trajectories of cortical myelination in adolescents and young adults: longitudinal validation and functional correlates. aug: au: Kwon, Dongjin Pfefferbaum, Adolf Sullivan, Edith V. Pohl, Kilian M. affil: Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA sug: subj: Nerve Fibers Physiology Brain Neuronal Plasticity Physiology Adolescence Adult Frontal Lobe Male Prospective Studies Female Nerve Tissue Metabolism Magnetic Resonance Imaging Methods Young Adult Brain Mapping Cross Sectional Studies Image Processing, Computer Assisted Clinical Assessment Tools Adolescent: 13-18 years Adult: 19-44 years Male Female ab: Adolescence is a time of continued cognitive and emotional evolution occurring with continuing brain development involving synaptic pruning and cortical myelination. The hypothesis of this study is that heavy myelination occurs in cortical regions with relatively direct, predetermined circuitry supporting unimodal sensory or motor functions and shows a steep developmental slope during adolescence (12-21 years) until young adulthood (22-35 years) when further myelination decelerates. By contrast, light myelination occurs in regions with highly plastic circuitry supporting complex functions and follows a delayed developmental trajectory. In support of this hypothesis, cortical myelin content was estimated and harmonized across publicly available datasets provided by the National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) and the Human Connectome Project (HCP). The cross-sectional analysis of 226 no-to-low alcohol drinking NCANDA adolescents revealed relatively steeper age-dependent trajectories of myelin growth in unimodal primary motor cortex and flatter age-dependent trajectories in multimodal mid/posterior cingulate cortices. This pattern of continued myelination showed smaller gains when the same analyses were performed on 686 young adults of the HCP cohort free of neuropsychiatric diagnoses. Critically, a predicted correlation between a motor task and myelin content in motor or cingulate cortices was found in the NCANDA adolescents, supporting the functional relevance of this imaging neurometric. Furthermore, the regional trajectory slopes were confirmed by performing longitudinally consistent analysis of cortical myelin. In conclusion, coordination of myelin content and circuit complexity continues to develop throughout adolescence, contributes to performance maturation, and may represent active cortical development climaxing in young adulthood. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|