Brain activity pattern changes after adaptive working memory training in multiple sclerosis.
Cognitive impairment and related abnormal brain activity are common in people with multiple sclerosis (PwMS). Adaptive training based on working memory (WM) has been shown to ameliorate cognitive symptoms, although the effects at a neural level are unclear. The aim of this study was to expand the ex...
| Published in: | Brain Imaging & Behavior Vol. 14; no. 1; pp. 142 - 155 |
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| Main Authors: | , , , , , , , |
| Format: | Journal Article |
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Springer Nature
Feb2020
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141624961&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141624961 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Feb2020 vid: 14 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 141624961 141624961 NLM30377931 10.1007/s11682-018-9984-z NLM30377931 141624961 ppf: 142 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Brain activity pattern changes after adaptive working memory training in multiple sclerosis. aug: au: Bonzano, Laura Pedullà, Ludovico Pardini, Matteo Tacchino, Andrea Zaratin, Paola Battaglia, Mario Alberto Brichetto, Giampaolo Bove, Marco affil: Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy sug: subj: Multiple Sclerosis Physiopathology Multiple Sclerosis Metabolism Adult Magnetic Resonance Imaging Middle Age Male Parietal Lobe Physiopathology Cognition Cerebral Cortex Physiopathology Brain Physiopathology Brain Mapping Cerebellum Physiopathology Learning Memory, Short Term Female Neuropsychological Tests Clinical Assessment Tools Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Cognitive impairment and related abnormal brain activity are common in people with multiple sclerosis (PwMS). Adaptive training based on working memory (WM) has been shown to ameliorate cognitive symptoms, although the effects at a neural level are unclear. The aim of this study was to expand the existing research on the effects of an adaptive WM rehabilitative intervention on brain functional activity in PwMS. A sample of eighteen PwMS performed an 8-week home-based cognitive rehabilitation treatment based on adaptive WM training. PwMS were assessed before and after treatment using a validated neuropsychological battery and undergoing an fMRI session while carrying out a cognitive task (i.e., Paced Visual Serial Addition Test - PVSAT). fMRI activations were compared to the activation pattern elicited by eighteen matched healthy subjects performing the same task. At baseline, we found abnormal brain activity during PVSAT in PwMS when compared to healthy subjects, with a pattern including several bilateral activation clusters. Following rehabilitation, PwMS improved cognitive performance, as evaluated by the neuropsychological battery, and showed a different activation map with clusters mainly located in the right cerebellum and in the left hemisphere. The only significant cluster in the right hemisphere was located in the inferior parietal lobule, and the BOLD signal extracted in this area significantly correlated with cognitive performance both before and after the treatment. We suggest that WM training can improve the cognitive performance and reduce the abnormal activation of PwMS by partially maintaining or even restoring brain cognitive function. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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