Klotho gene polymorphism, brain structure and cognition in early-life development.
Variation in the klotho gene is linked to differences in health outcomes: klotho allele KL-VS heterozygosity is associated with longevity, better cognition and greater right frontal grey matter volume in late life. Contradicting reports, however, suggest that KL-VS's effect on health might be age-de...
| Publicado en: | Brain Imaging & Behavior Vol. 14; no. 1; pp. 213 - 226 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Feb2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141624965&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141624965 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Feb2020 vid: 14 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 141624965 141624965 NLM30393836 10.1007/s11682-018-9990-1 NLM30393836 141624965 ppf: 213 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Klotho gene polymorphism, brain structure and cognition in early-life development. aug: au: de Vries, Clarisse F. Staff, Roger T. Noble, Kimberly G. Muetzel, Ryan L. Vernooij, Meike W. White, Tonya Waiter, Gordon D. Murray, Alison D. affil: Aberdeen Biomedical Imaging Centre, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, AB25 2ZD, Aberdeen, UK sug: subj: Glycoside Hydrolases Glycoside Hydrolases Metabolism Cognition Heterozygote Child, Preschool Polymorphism, Genetic Brain Physiology Genotype Adolescence Child Female Alleles Male Young Adult Genes Prospective Studies Questionnaires Child, Preschool: 2-5 years Adolescent: 13-18 years Child: 6-12 years Female Male ab: Variation in the klotho gene is linked to differences in health outcomes: klotho allele KL-VS heterozygosity is associated with longevity, better cognition and greater right frontal grey matter volume in late life. Contradicting reports, however, suggest that KL-VS's effect on health might be age-dependent. Here we examine the relationship between KL-VS genotype, cognition and brain structure in childhood and adolescence. We hypothesized that KL-VS has early influences on cognitive and brain development. We investigated the associations of KL-VS carrier status with cognition and brain morphology in a cohort of 1387 children and adolescents aged 3-21 years, examining main effects and interactions between age, sex and socioeconomic circumstance. KL-VS had no main effect on either cognition or brain structure, though there was a significant KL-VS × age interaction for cognition (specifically executive function, attention, episodic memory, and general cognition), total grey matter and total brain volume. KL-VS heterozygotes had better cognition than non-carriers before age 11, but lower cognition after age 11. Heterozygotes had smaller brains than non-carriers did in early childhood. Sex moderated the association between KL-VS and white matter volume. Among girls, KL-VS heterozygotes had smaller white matter volumes than non-carriers. Among boys, heterozygotes had greater white matter volumes than non-carriers. However, a replication in a cohort of 2306 children aged 6-12 years showed no significant associations. In contrast to findings in late life, these results show that KL-VS does not have a main effect on cognition and brain structure. Furthermore, KL-VS's influence may depend on age and sex. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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