Longitudinal investigation of cognitive deficits in breast cancer patients and their gray matter correlates: impact of education level.
Cognitive deficits are a major complaint in breast cancer patients, even before chemotherapy. Comprehension of the cerebral mechanisms related to cognitive impairment in breast cancer patients remains difficult due to the scarcity of studies investigating both cognitive and anatomical imaging change...
| Publicado en: | Brain Imaging & Behavior Vol. 14; no. 1; pp. 226 - 242 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Feb2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141624966&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141624966 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Feb2020 vid: 14 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 141624966 141624966 NLM30406352 10.1007/s11682-018-9991-0 NLM30406352 141624966 ppf: 226 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Longitudinal investigation of cognitive deficits in breast cancer patients and their gray matter correlates: impact of education level. aug: au: Perrier, Joy Viard, Armelle Levy, Christelle Morel, Nastassja Allouache, Djelila Noal, Sabine Joly, Florence Eustache, Francis Giffard, Bénédicte affil: Normandie Univ, UNICAEN, PSL University, EPHE, INSERM, U1077, CHU de Caen, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000, Caen, France sug: subj: Breast Neoplasms Psychosocial Factors Aged Atrophy Pathology Middle Age Quality of Life Breast Neoplasms Physiopathology Gray Matter Pathology Memory Female Attention Prospective Studies Adult Neuropsychological Tests Cognition Cognition Disorders Etiology Brain Pathology Ferrans and Powers Quality of Life Index Impact of Events Scale Aged: 65+ years Middle Aged: 45-64 years Adult: 19-44 years Female ab: Cognitive deficits are a major complaint in breast cancer patients, even before chemotherapy. Comprehension of the cerebral mechanisms related to cognitive impairment in breast cancer patients remains difficult due to the scarcity of studies investigating both cognitive and anatomical imaging changes. Furthermore, only some of the patients experienced cognitive decline following chemotherapy, yet few studies have identified risk factors for cognitive deficits in these patients. It has been shown that education level could impact cognitive abilities during the recovery phase following chemotherapy. Our main aim was to longitudinally evaluate cognitive and anatomical changes associated with cancer and chemotherapy in breast cancer patients. Our secondary aim was to assess the impact of education level on cognitive performances and gray matter (GM) atrophy in these patients. Twenty patients were included before chemotherapy (T1), 1 month (T2) and 1 year (T3) after chemotherapy. Twenty-seven controls without a history of cancer were assessed at T1 and T3 only. Cluster groups based on education level were defined for both groups and were further compared. Comparison between patients and controls revealed deficits in patients on verbal episodic memory retrieval at T1 and T3 and on executive functions at T3. After chemotherapy, breast cancer patients had GM atrophy that persisted or recovered 1 year after chemotherapy depending on the cortical areas. Increase in GM volumes from T1 to T3 were also found in both groups. At T2, patients with a higher level of education compared to lower level exhibited higher episodic memory retrieval and state anxiety scores, both correlating with cerebellar volume. This higher level of education group exhibited hippocampal atrophy. Our results suggest that, before chemotherapy, cancer-related processes impact cognitive functioning and that this impact seems exacerbated by the effect of chemotherapy on certain brain regions. Increase in GM volumes after chemotherapy were unexpected and warrant further investigations. Higher education level was associated, 1 month after the end of chemotherapy, with greater anxiety and hippocampal atrophy despite a lack of cognitive deficits. These results suggest, for the first time, the occurrence of compensation mechanisms that may be linked to cognitive reserve in relationship to state anxiety. This identification of factors, which may compensate cognitive impairment following chemotherapy, is critical for patient care and quality of life. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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