Associations of Liver Disease with Alcohol Use among People Living with HIV and the Role of Hepatitis C: The New Orleans Alcohol Use in HIV Study.
Aim This cross-sectional analysis of the New Orleans Alcohol Use in HIV (NOAH) study assesses whether current and lifetime alcohol use in people living with HIV (PLWH) are associated with greater liver disease and how hepatitis C-viral (HCV) co-infection (HIV/HCV+) modifies the association. Methods...
| Publicado en: | Alcohol & Alcoholism Vol. 55; no. 1; pp. 28 - 37 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Jan2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141628102&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141628102 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07350414 FA3 jtl: Alcohol & Alcoholism issn: 07350414 maglogo: N pubinfo: dt: Jan2020 vid: 55 iid: 1 pid: 622 pub: Oxford University Press / USA artinfo: ui: 141628102 141628102 141628102 10.1093/alcalc/agz089 141628102 ppf: 28 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Associations of Liver Disease with Alcohol Use among People Living with HIV and the Role of Hepatitis C: The New Orleans Alcohol Use in HIV Study. aug: au: Ferguson, Tekeda F Rosen, Erika Carr, Rotonya Brashear, Meghan Simon, Liz Theall, Katherine P Ronis, Martin J Welsh, David A Molina, Patricia E affil: Louisiana State University Health Sciences Center, Comprehensive Alcohol Research Center, 1901 Perdido Street, New Orleans, Louisiana 70112, LA, USA sug: subj: HIV-Positive Persons Liver Diseases Alcohol Drinking Hepatitis C Coinfection Human Cross Sectional Studies Comorbidity Questionnaires Clinical Assessment Tools Substance Use Disorders Diagnosis Phospholipids Blood Aminotransferases Blood Blood Platelets Fibrosis Nonalcoholic Fatty Liver Disease Multiple Logistic Regression Male Female Adult Middle Age Descriptive Statistics Binge Drinking Liver Cirrhosis Biological Markers Blood Sex Factors Odds Ratio Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Aim This cross-sectional analysis of the New Orleans Alcohol Use in HIV (NOAH) study assesses whether current and lifetime alcohol use in people living with HIV (PLWH) are associated with greater liver disease and how hepatitis C-viral (HCV) co-infection (HIV/HCV+) modifies the association. Methods Alcohol use was measured by Lifetime Drinking History (LDH), a 30-day Timeline Followback calendar, the Alcohol Use Disorder Identification Test, and phosphatidylethanol. Liver disease was estimated by alanine aminotransferase (ALT), aspartate aminotransferase (AST), AST platelet ratio-index (APRI), fibrosis-4 index (FIB-4) and nonalcoholic fatty liver disease-fibrosis score. Associations between alcohol consumption and liver disease were estimated with multivariable logistic regression. Models were adjusted for age, sex, body-mass index, hepatitis B and HIV viral load. Results Participants (N = 353) were majority male (69%) and black (84%) with a mean age of 48.3 ± 10 years. LDH was significantly associated with advanced liver fibrosis (FIB-4 aOR = 22.22 [1.22–403.72]) only among HIV/HCV+ participants with an LDH of 100–600 kg. HIV/HCV+ participants had a higher prevalence of intermediate and advanced liver disease markers than HIV/HCV− (P < 0.0001). Advanced markers of liver disease were most strongly associated with hazardous drinking (≥40(women)/60(men) grams/day) (APRI aOR = 15.87 (3.22–78.12); FIB-4 aOR = 6.76 (1.81–7.16)) and PEth ≥400 ng/ml (APRI aOR = 17.52 (2.55–120.54); FIB-4 aOR = 17.75 (3.30–95.630). Conclusion Results indicate a greater association of current alcohol use with liver disease than lifetime alcohol use, which varied by HCV status. These findings stress the importance of reducing alcohol use in PLWH to decrease risk of liver disease and fibrosis. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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