Vitamin D status in early childhood is not associated with cognitive development and linear growth at 6-9 years of age in North Indian children: a cohort study.
Background: Vitamin D is important for brain function and linear growth. Vitamin D deficiency during pregnancy has been linked with impaired neurodevelopment during early childhood. However, there is limited evidence from population-based studies on the long-term impact of vitamin D deficiency on co...
| Publicado en: | Nutrition Journal Vol. 19; no. 1; pp. 1 - 10 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
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BioMed Central
2/10/2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141662331&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141662331 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14752891 1CYY jtl: Nutrition Journal issn: 14752891 maglogo: N pubinfo: dt: 2/10/2020 vid: 19 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 141662331 141662331 NLM32041632 141662331 10.1186/s12937-020-00530-2 NLM32041632 141662331 ppf: 1 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Vitamin D status in early childhood is not associated with cognitive development and linear growth at 6-9 years of age in North Indian children: a cohort study. aug: au: Chowdhury, Ranadip Taneja, Sunita Kvestad, Ingrid Hysing, Mari Bhandari, Nita Strand, Tor A. affil: Centre for Health Research and Development, Society for Applied Studies, 45, Kalu Sarai, 110016, New Delhi, India sug: subj: Vitamin D Deficiency Epidemiology Prospective Studies Female Male India Cognition Child Comorbidity Human Vitamin D Comparative Studies Multicenter Studies Evaluation Research Validation Studies Clinical Assessment Tools Impact of Events Scale Child: 6-12 years Female Male ab: Background: Vitamin D is important for brain function and linear growth. Vitamin D deficiency during pregnancy has been linked with impaired neurodevelopment during early childhood. However, there is limited evidence from population-based studies on the long-term impact of vitamin D deficiency on cognitive development and linear growth. The objective of the current analysis is to examine whether vitamin D deficiency during infancy and early childhood is associated with cognitive development and linear growth measured in school age.Methods: This is a follow-up study of a placebo-controlled trial among 1000 North Indian children 6-30 months of age. We measured growth and neurodevelopment in 791 of these children when they were 6-9 years old. Neurodevelopment was measured using the Wechsler Intelligence Scale for Children, 4th edition INDIA, the Crichton Verbal Scale, NEPSY-II subtests, and the BRIEF 2. We categorized vitamin D concentrations during infancy and early childhood according to the US Institute of Medicine's recommendations; serum 25(OH)D < 12 ng/ml as deficient; 12-20 ng/ml as inadequate; > 20 ng/ml as sufficient. In multivariable regression models, adjusting for relevant confounders, we estimated the association between vitamin D status, growth and neurodevelopmental outcomes.Results: Among the 791 children, baseline vitamin D status was available for 716. Of these, 45.8% were vitamin D deficient, 32.7% were inadequate, and 21.5% were sufficient. Vitamin D status was not associated with any of the cognitive outcomes or linear growth [Adjusted β coefficient for height for age z-score between deficient and sufficient children was - 0.06 (95% CI - 0.24 to 0.11)] at follow up.Conclusion: Our findings do not support the notion that poor vitamin D status in early childhood is an important limitation for cognitive development and linear growth.Trial Registration: The trial was first registered at www.clinicaltrials.gov as NCT00717730 in July, 2008, and at CTRI/2010/091/001090 in August, 2010 and then as CTRI/2016/11/007494 in November 2016. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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