Ibrutinib-associated sever skin toxicity: A case of multiple inflamed skin lesions and cellulitis in a 68-year-old male patient with relapsed chronic lymphocytic leukemia – Case report and literature review.
Introduction: Ibrutinib is an oral inhibitor of Bruton's tyrosine kinase that is used for a variety of B cell hematological malignancies. Skin and subcutaneous tissue manifestations have been reported and were witnessed in up to 32% of the patients on ibrutinib. The mechanism in which ibrutinib can...
| Publicado en: | Journal of Oncology Pharmacy Practice Vol. 26; no. 2; pp. 487 - 492 |
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| Autores principales: | , , , , , , |
| Formato: | case study pictorial tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
Mar2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141717391&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141717391 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10781552 0JI jtl: Journal of Oncology Pharmacy Practice issn: 10781552 maglogo: Y pubinfo: dt: Mar2020 vid: 26 iid: 2 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 141717391 141717391 141717391 10.1177/1078155219856422 141717391 ppf: 487 ppct: 5 formats: tig: atl: Ibrutinib-associated sever skin toxicity: A case of multiple inflamed skin lesions and cellulitis in a 68-year-old male patient with relapsed chronic lymphocytic leukemia – Case report and literature review. aug: au: Ghasoub, R Albattah, A Elazzazy, S Alokka, R Nemir, A Alhijji, I Taha, R affil: 62850 -->National Center for Cancer Care and Research -->, Hamad Medical Corporation (HMC), Doha, Qatar sug: subj: Recurrence Drug Therapy Leukemia, Lymphocytic, Chronic Drug Therapy Tyrosine Kinase Inhibitors Adverse Effects Cellulitis Chemically Induced Lower Extremity Pathology Dermatitis Medicamentosa Drug Therapy Male Aged Tyrosine Kinase Inhibitors Administration and Dosage Administration, Oral Hyperpigmentation Pyoderma Chemically Induced Biopsy Antibiotics Therapeutic Use Cellulitis Drug Therapy Aged: 65+ years Male ab: Introduction: Ibrutinib is an oral inhibitor of Bruton's tyrosine kinase that is used for a variety of B cell hematological malignancies. Skin and subcutaneous tissue manifestations have been reported and were witnessed in up to 32% of the patients on ibrutinib. The mechanism in which ibrutinib can cause skin toxicities has been thought due to the inhibition of epidermal growth factor; c-Kit and platelet-derived growth factor receptor). Here, we report a case of an elderly chronic lymphocytic leukemia patient who developed multiple inflamed lesions and lower limb cellulitis in 100 days after initiating ibrutinib therapy. Case report: A 68-year-old male patient with relapsed chronic lymphocytic leukemia was started on ibrutinib 420 mg orally daily following multiple lines of therapy. Three months following ibrutinib, the patient developed multiple hyper pigmented lesions over both forearms then over both thighs; buttocks and lower limbs. The lesions were labeled as ecthyma and cellulitis that started as papules, which progressed to pustules. Management and outcomes: The patient required admission in which he received prolonged course of antibiotics. Biopsy from the wound showed soft tissue fragment infiltrated by acute and chronic inflammatory cells with necrosis; rare foreign body giant cells and granulation tissue formation; suggestive of abscess. Subsequently, ibrutinib was stopped permanently. Discussion: This is the first case description of an ibrutinib-associated sever skin toxicity in Qatar. The provided information regarding the clinical descriptions of toxicity profiles in general and skin-based in particular is valuable information for daily clinical practice, especially when selecting the optimum first-line treatment for the patient. pubtype: Academic Journal doctype: case study pictorial tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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