Binding of the D3-preferring antipsychotic candidate F17464 to dopamine D3 and D2 receptors: a PET study in healthy subjects with [11C]-(+)-PHNO.

Rationale: F17464, a dopamine D3 receptor antagonist with relatively high D3 selectivity (70 fold vs D2 in vitro), exhibits an antipsychotic profile in preclinical studies, and therapeutic efficacy was demonstrated in a randomized placebo-controlled clinical trial in patients with schizophrenia (Bit...

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Publicado en:	Psychopharmacology Vol. 237; no. 2; pp. 519 - 528
Autores principales:	Slifstein, Mark, Abi-Dargham, Anissa, Girgis, Ragy R, Suckow, Raymond F, Cooper, Thomas B, Divgi, Chaitanya R, Sokoloff, Pierre, Leriche, Ludovic, Carberry, Patrick, Oya, Shunichi, Joseph, Simon K, Guiraud, Marlène, Montagne, Agnès, Brunner, Valérie, Gaudoux, Florence, Tonner, Françoise
Formato:	Journal Article
Publicado:	Springer Nature Feb2020
Acceso en línea:	Ver este registro en EBSCOhost