The Many Faces of Cardiac Sarcoidosis.
Objectives: The objective of this study was to review and illustrate the sometimes diagnostically challenging features of cardiac sarcoidosis. We emphasize variable phenotypes presented at explant and biopsy evaluation and review literature regarding ancillary clinical and pathologic studies to enha...
| Publicado en: | American Journal of Clinical Pathology Vol. 153; no. 3; pp. 294 - 303 |
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| Autores principales: | , |
| Formato: | pictorial review Journal Article |
| Publicado: |
Oxford University Press / USA
Mar2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141735083&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141735083 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00029173 2RW jtl: American Journal of Clinical Pathology issn: 00029173 maglogo: N pubinfo: dt: Mar2020 vid: 153 iid: 3 pid: 10398 pub: Oxford University Press / USA artinfo: ui: 141735083 141735083 NLM31769474 141735083 10.1093/ajcp/aqz169 NLM31769474 141735083 ppf: 294 ppct: 9 formats: tig: atl: The Many Faces of Cardiac Sarcoidosis. aug: au: Serei, Virian D Fyfe, Billie affil: Department of Pathology and Laboratory Medicine, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ sug: subj: Myocardial Diseases Diagnosis Sarcoidosis Diagnosis Myocardium Pathology Macrophages Pathology Sarcoidosis Pathology Human Granuloma Pathology Myocardial Diseases Pathology ab: Objectives: The objective of this study was to review and illustrate the sometimes diagnostically challenging features of cardiac sarcoidosis. We emphasize variable phenotypes presented at explant and biopsy evaluation and review literature regarding ancillary clinical and pathologic studies to enhance diagnostic accuracy.Methods: A literature review was performed and two cardiac sarcoidosis cases were illustrated.Results: Our cases and literature review demonstrate the pathologic spectrum of cardiac sarcoidosis. Irregular left ventricular free wall involvement is most common, followed by the interventricular septum and right ventricle. Although granulomas are often composed of tight epithelioid macrophage aggregates, early granulomas comprise loosely associated macrophages with lymphocyte predominance. Chronic disease leads to fibrosis and end-stage heart failure. Sampling errors and variable histology cause low endomyocardial biopsy sensitivity.Conclusions: Current guidelines use clinical, radiologic, and immunohistologic criteria for diagnosing cardiac sarcoidosis. Knowledge of these guidelines will assist pathologists in making accurate diagnosis of this disease. pubtype: Academic Journal doctype: pictorial review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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