Performance and brain activity during the Wisconsin Card Sorting Test in adolescents with obsessive–compulsive disorder and adolescents with weight-restored anorexia nervosa.
Anorexia nervosa (AN) and obsessive–compulsive disorder (OCD) both show a peak age of onset during adolescence and share a number of phenotypic features, such as rigid rule-bound behavior and perseverative thinking. There is evidence of difficulties with set shifting or task switching in adults with...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 29; no. 2; pp. 217 - 227 |
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| Autores principales: | , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141752712&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141752712 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Feb2020 vid: 29 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 141752712 141752712 141752712 10.1007/s00787-019-01350-4 141752712 ppf: 217 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Performance and brain activity during the Wisconsin Card Sorting Test in adolescents with obsessive–compulsive disorder and adolescents with weight-restored anorexia nervosa. aug: au: Bohon, Cara Weinbach, Noam Lock, James affil: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, 94305-5719, Stanford, CA, USA sug: subj: Diagnosis, Brain Methods Magnetic Resonance Imaging Methods Wisconsin Card Sorting Test Obsessive-Compulsive Disorder Psychosocial Factors Anorexia Nervosa Psychosocial Factors Human Neuropsychological Tests Exploratory Research Female Adolescence Task Performance and Analysis Frontal Lobe Physiology Adolescent: 13-18 years Female ab: Anorexia nervosa (AN) and obsessive–compulsive disorder (OCD) both show a peak age of onset during adolescence and share a number of phenotypic features, such as rigid rule-bound behavior and perseverative thinking. There is evidence of difficulties with set shifting or task switching in adults with each disorder, but evidence in adolescents is limited. Furthermore, no studies have previously directly compared AN and OCD on this cognitive process or examined comparative neural correlates. This study provides exploratory analyses to address this gap by measuring brain activity with functional magnetic resonance imaging (fMRI) during a computerized version of the Wisconsin Card Sorting Test (WCST) in female adolescents with weight-restored AN (WR-AN) (n = 14), OCD (n = 11), and healthy controls (n = 24). Results revealed greater perseverative errors in the OCD group than healthy controls and WR-AN, but no difference between WR-AN and healthy controls. Greater activity in the right front pole, inferior frontal gyrus, and middle frontal gyrus during the task (compared to a control matching task) was associated with more perseverative errors in the OCD group, but not healthy controls. The correlation between perseverative errors and brain response to the task in the WR–AN group was not different from either comparison group. These findings propose a hypothesis that behavioral similarities between OCD and AN, as well as difficulties with set shifting in adults with AN, are driven by obsessive–compulsive features present in AN rather than a shared underlying neurocognitive signature. This notion should be tested in larger samples in future studies. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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