Adult mood problems in children with neurodevelopmental problems: evidence from a prospective birth cohort followed to age 50.
Purpose: Specific child neurodevelopmental (ND) disorders such as ADHD and learning problems are associated with concurrent and future (up to early adulthood) mood problems. However, it is unclear whether findings generalise to population traits as well as diagnoses, to general as well as specific n...
| Publicado en: | Social Psychiatry & Psychiatric Epidemiology Vol. 55; no. 3; pp. 351 - 359 |
|---|---|
| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Mar2020
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141752731&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141752731 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09337954 EJG jtl: Social Psychiatry & Psychiatric Epidemiology issn: 09337954 maglogo: N pubinfo: dt: Mar2020 vid: 55 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 141752731 141752731 NLM31119307 10.1007/s00127-019-01727-5 NLM31119307 141752731 ppf: 351 ppct: 8 formats: tig: atl: Adult mood problems in children with neurodevelopmental problems: evidence from a prospective birth cohort followed to age 50. aug: au: Addicoat, Alishia Thapar, Ajay K. Riglin, Lucy Thapar, Anita Collishaw, Stephan affil: Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Child and Adolescent Psychiatry, Hadyn Ellis Building, Maindy Road, CF24 4HQ, Cardiff, Wales, UK sug: subj: Depression Affect Anxiety Child Female Adult Child, Preschool Young Adult Middle Age Male Prospective Studies Cognition Barthel Index Questionnaires Child: 6-12 years Adult: 19-44 years Child, Preschool: 2-5 years Middle Aged: 45-64 years Female Male ab: Purpose: Specific child neurodevelopmental (ND) disorders such as ADHD and learning problems are associated with concurrent and future (up to early adulthood) mood problems. However, it is unclear whether findings generalise to population traits as well as diagnoses, to general as well as specific neurodevelopmental domains, and whether risk associations extend to later adulthood or diminish with age.Methods: We used data from a UK cohort of children born in 1958, the National Child Development Study (NCDS). ND problems were assessed at ages 7 and 11 years with parent- and teacher ratings of restlessness, hyperactivity and motor co-ordination difficulties, and by individual tests of reading, arithmetic and general cognitive ability. Mood (depression/anxiety) problems were assessed using the Malaise symptom screen at 23, 33, 42, and 50 years. Factor analyses were conducted to assess whether the specific neurodevelopmental domains could be aggregated into a general "ND" latent factor as well as specific factors. Associations with mood outcomes were then tested.Results: A bi-factor model with a general "ND" latent factor and specific "motor" and "cognition" factors fits the data well. The specific cognition and motor factor scores were associated with mood problems in early adulthood only. The "ND" factor demonstrated associations with mood problems at each adult follow-up (men - age 23 years: β = 0.17; age 33: β = 0.16; age 42: β = 0.14; age 50: β = 0.16; women - 23 years: β = 0.25; 33 years: β = 0.26; 42 years: β = 0.14; 50 years: β = 0.16; all ps < 0.01). Interactions by sex indicated that the association between this general factor and mood problems was more pronounced for women than men at ages 23 years (β = 0.09, p = 0.005) and 33 years (β = 0.10, p = 0.003), but not at 42 or 50 years (ps > 0.8).Conclusions: Our results suggest that, in a population-based cohort, a general, childhood neurodevelopmental difficulty factor is stably associated with mood problems in adult life. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|