Outcomes of classic lobular neoplasia diagnosed on breast core needle biopsy: a retrospective multi-center study.
Management of classic lobular neoplasia (cLN) diagnosed on core needle biopsy (CNB) is controversial. Our aim in this study was to review cases of cLN diagnosed on CNB to determine the rate and risk factors of an upgrade to ductal carcinoma in situ (DCIS) or invasive carcinoma on excision. All breas...
| Publicado en: | Virchows Archiv: European Journal of Pathology Vol. 476; no. 2; pp. 209 - 218 |
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| Autores principales: | , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Feb2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141807682&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141807682 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09456317 O1Z jtl: Virchows Archiv: European Journal of Pathology issn: 09456317 maglogo: N pubinfo: dt: Feb2020 vid: 476 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 141807682 141807682 NLM31776645 141807682 10.1007/s00428-019-02685-8 NLM31776645 141807682 ppf: 209 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Outcomes of classic lobular neoplasia diagnosed on breast core needle biopsy: a retrospective multi-center study. aug: au: Genco, Iskender Sinan Tugertimur, Bugra Chang, Qing Cassell, Lauren Hajiyeva, Sabina affil: Department of Pathology and Laboratory Medicine, Northwell Health Lenox Hill Hospital,, 100 E 77th Street, 10075, New York, NY, USA sug: subj: Carcinoma, Lobular Pathology Breast Neoplasms Diagnosis Biopsy, Needle Methods Breast Neoplasms Pathology Adult Breast Pathology Female Precancerous Conditions Pathology Adenocarcinoma Pathology Middle Age Aged, 80 and Over Aged Retrospective Design Carcinoma in Situ Pathology Carcinoma, Lobular Diagnosis Personal Resource Questionnaire Human Adult: 19-44 years Middle Aged: 45-64 years Aged, 80 & over Aged: 65+ years Female ab: Management of classic lobular neoplasia (cLN) diagnosed on core needle biopsy (CNB) is controversial. Our aim in this study was to review cases of cLN diagnosed on CNB to determine the rate and risk factors of an upgrade to ductal carcinoma in situ (DCIS) or invasive carcinoma on excision. All breast CNBs with a diagnosis of atypical lobular hyperplasia (ALH) or classic lobular carcinoma in situ (cLCIS) from three different institutions within a single health care system between 2013 and 2018 were retrieved. Cases with any additional high-risk lesions in the same CNB or discordant radiological-pathological correlation were excluded. Information about age, personal history of prior or concurrent breast cancer (P/CBC), and radiological and histological findings were recorded. A total of 287 cLN cases underwent surgical excision. Analysis of these 287 cLN cases showed 11 (3.8%) upgrade lesions on excision. Among the 172 ALH cases, there were 3 (1.7%) upgrades, which were all invasive lobular carcinomas (ILCs). On the other hand, 8 of 115 (7%) cLCIS cases revealed upgrade on excision (2 ILC, 5 DCIS. and 1 ILC + DCIS). Statistical analysis revealed that cLN cases with P/CBC, radiological asymmetry, or architectural distortion had a statistically significant higher upgrade rate on excision. Our findings revealed a low upgrade rate (3.8%) on the excision of classic lobular neoplasia diagnosed on breast core needle biopsy. Clinicoradiological surveillance can be appropriate when lobular neoplasia is identified on core biopsy with pathological radiological concordance in patients without a history of breast cancer, with the caveat that radiological asymmetry and architectural distortion are associated with a significant increase in an upgrade on excision. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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