Precancerous Gastric Lesions with Helicobacter pylori vacA+/babA2+/oipA+ Genotype Increase the Risk of Gastric Cancer.
Objective. The clinical outcomes of gastric diseases such as chronic gastritis, peptic ulcer, and gastric cancer have been attributed to the interplay of virulence factors of Helicobacter pylori (H. pylori), host genetic susceptibility, and host immune responses. This study investigated the presence...
| Publicado en: | BioMed Research International pp. 1 - 9 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
2/19/2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141922451&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141922451 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 2/19/2020 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 141922451 141922451 141922451 10.1155/2020/7243029 141922451 ppf: 1 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Precancerous Gastric Lesions with Helicobacter pylori vacA+/babA2+/oipA+ Genotype Increase the Risk of Gastric Cancer. aug: au: Bartpho, Theeraya Simawaranon Wattanawongdon, Wareeporn Tongtawee, Taweesak Paoin, Chatchanok Kangwantas, Kokiet Dechsukhum, Chavaboon affil: Translational Medicine Programs, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand sug: subj: Helicobacter Infections Complications Virulence Evaluation Genotype Evaluation Precancerous Conditions Risk Factors Stomach Neoplasms Risk Factors Stomach Neoplasms Familial and Genetic Precancerous Conditions Familial and Genetic Risk Assessment Human Chronic Disease Gastritis Diagnosis Gastritis, Atrophic Diagnosis Intestines Pathology Metaplasia Diagnosis Gastritis Surgery Gastritis, Atrophic Surgery Metaplasia Surgery Endoscopy Methods Surgery, Operative Methods Polymerase Chain Reaction Methods Multiple Regression Stomach Neoplasms Prognosis Survival Prevalence Odds Ratio Confidence Intervals Gastritis Risk Factors ab: Objective. The clinical outcomes of gastric diseases such as chronic gastritis, peptic ulcer, and gastric cancer have been attributed to the interplay of virulence factors of Helicobacter pylori (H. pylori), host genetic susceptibility, and host immune responses. This study investigated the presence of cagA, vacA, iceA2, babA2, and oipA genes and their association with clinical outcomes. Methods. Chronic gastritis, atrophic gastritis, and intestinal metaplasia specimens were obtained from patients who underwent endoscopy and surgical resection between January 2017 and December 2018; specimens from gastric cancer patients treated between January 2014 and December 2018 were also added. H. pylori infection and virulence genes (cagA, vacA, iceA2, babA2, and oipA) were determined using real-time PCR. The association between H. pylori genotypes and clinical outcomes were evaluated using multivariate regression model analysis. The overall survival of gastric cancer patients was compared between genotype combinations. Results. H. pylori was positive in 166 patients with chronic gastritis, precancerous gastric lesions, and gastric cancer. The genes vacA, babA2, and oipA were most prevalent in chronic gastritis (73%), precancerous gastric lesions (62%), and gastric cancer (91%), respectively. The vacA, babA2, and oipA genes were associated with increased risk of gastric cancer (OR = 1.23; 95% CI = 1.13–3.32; P = 0.033 , OR = 2.64; 95% CI = 1.44–4.82, P = 0.024 , and OR = 2.79; 95% CI = 1.58–5.41; P = 0.031 , respectively). Interestingly, H. pylori vacA+/babA2+/oipA+ genotype infection was associated with increased risk of gastric cancer (OR = 3.85, 95% CI = 1.67–5.77, P = 0.014). Conclusion. In this present study, we reported on the virulence genes of H. pylori infection to reveal their association with increased risk of chronic gastritis, precancerous gastric lesions, and gastric cancer. Precancerous gastric lesions with H. pylori vacA+/babA2+/oipA+ genotype increased the risk of gastric cancer. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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