The Development of a Tympanic Membrane Model and Probabilistic Dose-Response Risk Assessment of Rupture Because of Blast.
Introduction: There is no dose-response model available for the assessment of the risk of tympanic membrane rupture (TMR), commonly known as eardrum rupture, from exposures to blast from nonlethal flashbangs, which can occur concurrently with temporary threshold shift. Therefore, the objective of th...
| Publicado en: | Military Medicine Vol. 185; pp. 234 - 243 |
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| Autores principales: | , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
2020 Supplement
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141923051&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141923051 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00264075 4DV jtl: Military Medicine issn: 00264075 maglogo: N pubinfo: dt: 2020 Supplement vid: 185 pid: 622 pub: Oxford University Press / USA artinfo: ui: 141923051 141923051 NLM32074353 141923051 10.1093/milmed/usz215 NLM32074353 141923051 ppf: 234 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The Development of a Tympanic Membrane Model and Probabilistic Dose-Response Risk Assessment of Rupture Because of Blast. aug: au: Iyoho, Anthony E Ho, Kevin Chan, Philemon affil: L-3 Applied Technologies Inc., 10180 Barnes Canyon Road, San Diego, CA 92121 sug: subj: Tympanic Membrane Physiopathology Pressure Adverse Effects Disasters Classification Blast Injuries Complications Tympanic Membrane Perforation Etiology Blast Injuries Physiopathology Human Tympanic Membrane Injuries Finite Element Analysis Risk Assessment Methods ROC Curve Disasters Cadaver Tympanic Membrane Perforation Physiopathology Validation Studies Comparative Studies Evaluation Research Multicenter Studies ab: Introduction: There is no dose-response model available for the assessment of the risk of tympanic membrane rupture (TMR), commonly known as eardrum rupture, from exposures to blast from nonlethal flashbangs, which can occur concurrently with temporary threshold shift. Therefore, the objective of this work was to develop a fast-running, lumped parameter model of the tympanic membrane (TM) with probabilistic dose-dependent prediction of injury risk.Materials and Methods: The lumped parameter model was first benchmarked with a finite element model of the middle ear. To develop the dose-response curves, TMR data from a historic cadaver study were utilized. From these data, the binary probability response was constructed and logistic regression was applied to generate the respective dose-response curves at moderate and severe eardrum rupture severity.Results: Hosmer-Lemeshow statistical and receiver operation characteristic analyses showed that maximum stored TM energy was the overall best dose metric or injury correlate when compared with total work and peak TM pressure.Conclusions: Dose-response curves are needed for probabilistic risk assessments of unintended effects like TMR. For increased functionality, the lumped parameter model was packaged as a software library that predicts eardrum rupture for a given blast loading condition. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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