Considerations for Development of Exposure Limits for Chemicals Encountered During Aircraft Operation.
Background: Military aircrews' health status is critical to their mission readiness, as they perform physically and cognitively demanding tasks in nontraditional work environments. Research Objectives: Our objective is to develop a broad operational risk assessment framework and demonstrate its appl...
| Published in: | Military Medicine Vol. 185; pp. 390 - 396 |
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| Main Authors: | , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Oxford University Press / USA
2020 Supplement
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141923109&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141923109 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00264075 4DV jtl: Military Medicine issn: 00264075 maglogo: N pubinfo: dt: 2020 Supplement vid: 185 pid: 622 pub: Oxford University Press / USA artinfo: ui: 141923109 141923109 NLM32074307 141923109 10.1093/milmed/usz318 NLM32074307 141923109 ppf: 390 ppct: 6 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Considerations for Development of Exposure Limits for Chemicals Encountered During Aircraft Operation. aug: au: Sweeney, Lisa M Gearhart, Jeffery M Ott, Darrin K Pangburn, Heather A affil: UES, Inc., 4401 Dayton-Xenia Road, Beavercreek, OH 45432, assigned to U.S. Air Force School of Aerospace Medicine, Wright-Patterson Air Force Base, OH sug: subj: Hazardous Materials Analysis Occupational Exposure Analysis Aircraft Equipment and Supplies United States Benzene Derivatives Blood Occupational Exposure United States Environmental Protection Agency Statistics and Numerical Data Aircraft Statistics and Numerical Data Aerospace Medicine Statistics and Numerical Data Human Benzene Derivatives Analysis Aerospace Medicine Methods United States Environmental Protection Agency Administration Risk Assessment Methods Hazardous Materials Blood Validation Studies Comparative Studies Evaluation Research Multicenter Studies ab: Background: Military aircrews' health status is critical to their mission readiness, as they perform physically and cognitively demanding tasks in nontraditional work environments. Research Objectives: Our objective is to develop a broad operational risk assessment framework and demonstrate its applicability to health risks to aircrews because of airborne chemical exposure, considering stressors such as heat and exertion.Methods: Extrapolation of generic exposure standards to military aviation-specific conditions can include computation of risk-relevant internal dosimetry estimates by incorporating changes in breathing patterns and blood flow distribution because of aspects of the in-flight environment. We provide an example of the effects of exertion on peak blood concentrations of 1,2,4-trimethylbenzene computed using a physiologically based pharmacokinetic model.Results: Existing published collections on the effects of flight-related stressors on breathing patterns and blood flow address only a limited number of stressors. Although data exist that can be used to develop operational exposure limits specific to military aircrew activities, efforts to integrate this information in specific chemical assessments have been limited.Conclusions: Efforts to develop operational exposure limits would benefit from guidance on how to make use of existing assessments and expanded databases of the impact of environmental stressors on adult human physiology. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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