Locally Advanced Rectal Cancer: Treatment Approach in Elderly Patients.
Independently of age, evidence-based guidelines recommend a multidisciplinary treatment approach in patients with locally advanced rectal cancer (LARC). But actually, elderly patients are grossly underrepresented in clinical trials, accounting < 10% of enrolled cases. Therefore, LARC management in e...
| Publicado en: | Current Treatment Options in Oncology Vol. 21; no. 1; pp. 1 - 13 |
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| Autores principales: | , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jan2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141945653&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141945653 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15272729 3KHC jtl: Current Treatment Options in Oncology issn: 15272729 maglogo: N pubinfo: dt: Jan2020 vid: 21 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 141945653 141945653 NLM31927649 141945653 10.1007/s11864-019-0692-8 NLM31927649 141945653 ppf: 1 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Locally Advanced Rectal Cancer: Treatment Approach in Elderly Patients. aug: au: De Felice, Francesca Crocetti, Daniele Maiuri, Veronica Parisi, Martina Marampon, Francesco Izzo, Luciano De Toma, Giorgio Musio, Daniela Tombolini, Vincenzo affil: Department of Radiotherapy, Policlinico Umberto I, "Sapienza" University of Rome, Viale Regina Elena 326, 00161, Rome, Italy sug: subj: Rectal Neoplasms Therapy Rectal Neoplasms Diagnosis Age Factors Algorithms Human Treatment Outcomes Aged Prognosis Comorbidity Male Disease Management Neoplasm Metastasis Neoplasm Staging Combined Modality Therapy Female Rectal Neoplasms Etiology Rectal Neoplasms Mortality Questionnaires Aged: 65+ years Male Female ab: Independently of age, evidence-based guidelines recommend a multidisciplinary treatment approach in patients with locally advanced rectal cancer (LARC). But actually, elderly patients are grossly underrepresented in clinical trials, accounting < 10% of enrolled cases. Therefore, LARC management in elderly patients remains a crucial issue in daily practice, especially due to their frailty. Multiple clinical factors, including general health status, cognitive status, co-morbidity, disability, and life expectancy should be considered to understand the complexities of geriatric assessment and then define therapy. We use a patient-centered approach in order to tailor the optimal treatment strategy. We treat fit elderly patients as younger patients, including neoadjuvant chemoradiotherapy (CRT), surgery, and adjuvant chemotherapy. Whereas, in vulnerable and frail patients, we propose standard CRT (vulnerable patients) or radiotherapy alone (frail patients). pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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