Acute post‐streptococcal glomerulonephritis in Central Australia.

Objective: To determine the incidence, clinical presentation and progress of acute post‐streptococcal glomerulonephritis in Central Australia. Design: Retrospective observational analysis. Setting: Paediatric inpatient admission at Alice Springs Hospital. Participants: Patients admitted to Alice Spr...

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Publicado en:Australian Journal of Rural Health Vol. 28; no. 1; pp. 74 - 81
Autores principales: Dowler, James, Wilson, Angela
Formato: research tables/charts Journal Article
Publicado: Wiley-Blackwell Feb2020
Acceso en línea:Ver este registro en EBSCOhost
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      jtl: Australian Journal of Rural Health
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      dt: Feb2020
      vid: 28
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        10.1111/ajr.12568
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        atl: Acute post‐streptococcal glomerulonephritis in Central Australia.
      aug:
        au:
          Dowler, James
          Wilson, Angela
        affil: Alice Springs Hospital, Flinders University College of Medicine and Public Health, Alice Springs Northern Territory,, Australia
      sug:
        subj:
          Acute Disease
          Streptococcal Infections In Infancy and Childhood
          Glomerulonephritis Epidemiology
          Glomerulonephritis Symptoms
          Human
          Australia
          Retrospective Design
          Nonexperimental Studies
          Pediatric Care
          Hospitals
          Descriptive Statistics
          Incidence
          Skin Diseases, Infectious
          Comorbidity
          Biochemistry
          Electronic Health Records
          Confidence Intervals
          Hospitalization
          Infant
          Child, Preschool
          Child
          Male
          Female
          Prospective Studies
          Laboratories
          Kidney Ultrasonography
          Complement
          Kidney Diseases
          Aboriginal Australians
          Infant: 1-23 months
          Child, Preschool: 2-5 years
          Child: 6-12 years
          Male
          Female
      ab: Objective: To determine the incidence, clinical presentation and progress of acute post‐streptococcal glomerulonephritis in Central Australia. Design: Retrospective observational analysis. Setting: Paediatric inpatient admission at Alice Springs Hospital. Participants: Patients admitted to Alice Springs Hospital under 14 years of age meeting diagnostic criteria for acute post‐streptococcal glomerulonephritis between January 2010 and December 2014. Main Outcome Measures: Incidence of acute post‐streptococcal glomerulonephritis in central Australia. Biochemical abnormalities associated with acute post‐streptococcal glomerulonephritis. Co‐occuring conditions. Results: Sixty‐nine out of the 174 cases reviewed were identified as having either acute post‐streptococcal glomerulonephritis (63) or probable acute post‐streptococcal glomerulonephritis (6). We calculate the incidence of APSGN admission to be higher than previously reported and the highest reported incidence globally in children. Clinical evidence of skin infection was frequently documented. Co‐occurring infections were common, including scabies/head lice, urinary tract infection and pneumonia. Fifty‐three patients showed biochemical evidence of acute kidney injury. Conclusions: Aboriginal children in Central Australia have the highest incidence of acute post‐streptococcal glomerulonephritis reported worldwide. Urgent action is required to improve housing and reduce overcrowding in Central Australian towns and communities to reduce the burden of disease of skin infection and Group A Streptococcus related diseases. Without effective change in living conditions, it is unlikely that there will be a significant change in the morbidity related to these conditions.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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