Recovery of original individual person data (IPD) inferences from empirical IPD summaries only: Applications to distributed computing under disclosure constraints.
There are many settings where individual person data (IPD) are not available, due to privacy or technical reasons, and one must work with IPD proxies, such as summary statistics, to approximate original IPD inferences, that is, the results of statistical analyses that would ideally have been perform...
| Published in: | Statistics in Medicine Vol. 39; no. 8; pp. 1183 - 1199 |
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| Main Authors: | , , |
| Format: | research Journal Article |
| Published: |
Wiley-Blackwell
4/15/2020
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141996442&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141996442 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02776715 2DZ jtl: Statistics in Medicine issn: 02776715 maglogo: Y pubinfo: dt: 4/15/2020 vid: 39 iid: 8 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 141996442 141996442 145824896 NLM31944335 141996442 10.1002/sim.8470 NLM31944335 141996442 ppf: 1183 ppct: 16 formats: tig: atl: Recovery of original individual person data (IPD) inferences from empirical IPD summaries only: Applications to distributed computing under disclosure constraints. aug: au: Bonofiglio, Federico Schumacher, Martin Binder, Harald affil: Institute of Medical Biometry and Statistics, Faculty of Medicine, Medical Center University of Freiburg, Freiburg, Germany sug: subj: Study Design Truth Disclosure Logistic Regression Data Analysis, Statistical Human Data Security Comparative Studies Multicenter Studies Evaluation Research Validation Studies Scales Funding Source ab: There are many settings where individual person data (IPD) are not available, due to privacy or technical reasons, and one must work with IPD proxies, such as summary statistics, to approximate original IPD inferences, that is, the results of statistical analyses that would ideally have been performed on individual-level data. For instance, in a distributed computing setting, as implemented in the DataSHIELD software framework, different centers can only share IPD proxies to obtain pooled IPD inferences. Such privacy requirements limit the scope of statistical investigation. For example, it can be challenging to perform between-center random-effect regression models. To increase modeling freedom we propose a method that only uses simple nondisclosive summaries of the original IPD as input, such as empirical marginal moments and correlation matrices, and generates artificial data compatible with those summary features. Specifically, data are generated from a Gaussian copula with marginal and joint components specified by the above summaries. The goal is to reproduce original IPD features in the artificial data, such that original IPD inferences are recovered from the artificial data. In an application example, and through simulations, we show that we can recover estimates of a multivariable IPD random-effect logistic regression, from artificial data generated via the Gaussian copula using the above IPD summaries, suggesting the proposed approach provides a generally applicable strategy for distributed computing settings with data protection constraints. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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