The current Indian epidemic of dermatophytosis: A study on causative agents and sensitivity patterns.
Background: In the recent years, the frequency, severity, clinical characteristics, treatment response, and relapse rate of dermatophytosis have dramatically changed in India. Given the surge in dermatophytosis, we had undertaken a study to isolate and identify the common species causing dermatophyt...
| Publicado en: | Indian Journal of Dermatology Vol. 65; no. 2; pp. 118 - 123 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wolters Kluwer India Pvt Ltd
Mar/Apr2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142045889&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142045889 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00195154 259H jtl: Indian Journal of Dermatology issn: 00195154 maglogo: N pubinfo: dt: Mar/Apr2020 vid: 65 iid: 2 pid: 16919 pub: Wolters Kluwer India Pvt Ltd artinfo: ui: 142045889 142045889 142045889 10.4103/ijd.IJD_203_19 142045889 ppf: 118 ppct: 5 formats: tig: atl: The current Indian epidemic of dermatophytosis: A study on causative agents and sensitivity patterns. aug: au: Das, Sudip De, Abhishek Saha, Rajdeep Sharma, Nidhi Khemka, Monika Singh, Sonal Hesanoor Reja, Abu Kumar, Purushottam affil: Department of Dermatology, Calcutta National Medical College, Kolkata, West Bengal sug: subj: Tinea Diagnosis Tinea Drug Therapy Antifungal Agents Therapeutic Use Human India In Vitro Studies Microscopy Staining and Labeling Fungi Itraconazole Microbial Culture and Sensitivity Tests Culture Media Tinea Etiology Tinea Epidemiology ab: Background: In the recent years, the frequency, severity, clinical characteristics, treatment response, and relapse rate of dermatophytosis have dramatically changed in India. Given the surge in dermatophytosis, we had undertaken a study to isolate and identify the common species causing dermatophyte infection and to know the in vitro efficacy of the common antifungals against them. Materials and Methods: total of 103 new cases that were not on any treatment for the past 3 months were included. Skin scrapings were collected for direct microscopic examination and for fungal culture in Sabouraud 4% dextrose agar (SDA) with chloramphenicol and cycloheximide slant tubes, and dermatophyte test media. Fungi were identified on the basis of their macroscopic and microscopic features with the help of lactophenol cotton blue staining and urease test. Also, the drug sensitivity of the dermatophytes was tested with the common antifungals. Results: Of the 55 cases (53.4%) that were positive for dermatophytes in the culture, 29 showed possible contamination. Trichophyton was the predominant organism (49 cases) with T. verrucosum being the commonest species (26 cases), followed by T. rubrum (15 patients), and T. mentagrophytes(8 cases). All species of Trichophyton were found to be most sensitive to itraconazole amongst systemic antifungals and luliconazole amongst topical antifungals. Conclusion: This study concluded that the causative agent for the dermatophytosis was changing in India and in our subset, T. verrucosum caused the maximum number of infections. Itraconazole and luliconazole had the highest sensitivity amongst systemic and topical antifungals, respectively. It also showed that terbinafine had comparatively less sensitivity to most organisms. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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