Long-term all-cause mortality and cardiovascular outcomes in Scottish children after initiation of renal replacement therapy: a national cohort study.
Background: Data on long-term outcomes in children who have received renal replacement therapy (RRT) for end-stage renal disease are limited. Methods: We studied long-term survival and incidence of fatal and nonfatal cardiovascular disease (CVD) events and determinants of these outcomes in children...
| Publicado en: | Pediatric Nephrology Vol. 35; no. 4; pp. 677 - 686 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142063078&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142063078 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Apr2020 vid: 35 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 142063078 142063078 142063078 10.1007/s00467-019-04430-4 142063078 ppf: 677 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Long-term all-cause mortality and cardiovascular outcomes in Scottish children after initiation of renal replacement therapy: a national cohort study. aug: au: Galiyeva, Dinara B. Jackson, Caroline A. Wild, Sarah H. Burns, Susan Hughes, David Traynor, Jamie P. Metcalfe, Wendy Halbesma, Nynke affil: Usher Institute, University of Edinburgh, Edinburgh, UK sug: subj: Kidney Failure, Chronic Therapy Renal Replacement Therapy Adverse Effects Kidney Failure, Chronic Mortality Cardiovascular Diseases Mortality Scotland Human Female Male Child Descriptive Statistics Confidence Intervals Kidney Transplantation Dialysis Incidence Sex Factors Child: 6-12 years Female Male ab: Background: Data on long-term outcomes in children who have received renal replacement therapy (RRT) for end-stage renal disease are limited. Methods: We studied long-term survival and incidence of fatal and nonfatal cardiovascular disease (CVD) events and determinants of these outcomes in children who initiated RRT between 1961 and 2013 using data from the Scottish Renal Registry (SRR). Linkage to morbidity records was available from 1981. Results: A total of 477 children of whom 55% were boys, almost 50% had congenital urinary tract disease (CAKUT), 10% received a transplant as the first mode of RRT and almost 60% were over 11 years of age at start of RRT were followed for a median of 17.8 years (interquartile range (IQR) 8.7–26.6 years). Survival was 87.3% (95% confidence interval (CI) 84.0–90.1) at 10 years and 77.6% (95% CI 73.3–81.7) at 20 years. During a median follow-up of 14.96 years (IQR 7.1–22.9), 20.9% of the 381 patients with morbidity data available had an incident of CVD event. Age < 2 years at start of RRT, receiving dialysis rather than a kidney transplant and primary renal disease (PRD) other than CAKUT or glomerulonephritis (GN), were associated with a higher risk of all-cause mortality. Male sex, receiving dialysis rather than a kidney transplant and PRD other than CAKUT or GN, was associated with a higher risk of CVD incidence. Conclusions: Mortality and CVD incidence among children receiving RRT are high. PRD and RRT modality were associated with increased risk of both all-cause mortality and CVD incidence. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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