Short‐wave infrared light imaging measures tissue moisture and distinguishes superficial from deep burns.
Existing clinical approaches and tools to measure burn tissue destruction are limited resulting in misdiagnosis of injury depth in over 40% of cases. Thus, our objective in this study was to characterize the ability of short‐wave infrared (SWIR) imaging to detect moisture levels as a surrogate for t...
| Publicado en: | Wound Repair & Regeneration Vol. 28; no. 2; pp. 185 - 194 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Mar2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142101429&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142101429 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10671927 DPV jtl: Wound Repair & Regeneration issn: 10671927 maglogo: Y pubinfo: dt: Mar2020 vid: 28 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 142101429 142101429 145790830 142101429 10.1111/wrr.12779 142101429 ppf: 185 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Short‐wave infrared light imaging measures tissue moisture and distinguishes superficial from deep burns. aug: au: Mironov, Sergey Hwang, Charles D. Nemzek, Jean Li, John Ranganathan, Kavitha Butts, Jonathan T. Cholok, David J. Dolgachev, Vladislav A. Wang, Stewart C. Hemmila, Mark Cederna, Paul S. Morris, Michael D. Berenfeld, Omer Levi, Benjamin affil: Center for Arrhythmia Research, University of Michigan, Ann Arbor Michigan sug: subj: Tissue Analysis Body Water Analysis Biological Phenomena Spectrophotometry, Infrared Methods Diagnostic Imaging Methods Burns Diagnosis Validity Evaluation Animal Studies Descriptive Statistics Biopsy In Vivo Studies Mice Swine Validation Studies Histology ab: Existing clinical approaches and tools to measure burn tissue destruction are limited resulting in misdiagnosis of injury depth in over 40% of cases. Thus, our objective in this study was to characterize the ability of short‐wave infrared (SWIR) imaging to detect moisture levels as a surrogate for tissue viability with resolution to differentiate between burns of various depths. To accomplish our aim, we constructed an imaging system consisting of a broad‐band Tungsten light source; 1,200‐, 1,650‐, 1,940‐, and 2,250‐nm wavelength filters; and a specialized SWIR camera. We initially used agar slabs to provide a baseline spectrum for SWIR light imaging and demonstrated the differential absorbance at the multiple wavelengths, with 1,940 nm being the highest absorbed wavelength. These spectral bands were then demonstrated to detect levels of moisture in inorganic and in vivo mice models. The multiwavelength SWIR imaging approach was used to diagnose depth of burns using an in vivo porcine burn model. Healthy and injured skin regions were imaged 72 hours after short (20 seconds) and long (60 seconds) burn application, and biopsies were extracted from those regions for histologic analysis. Burn depth analysis based on collagen coagulation histology confirmed the formation of superficial and deep burns. SWIR multispectral reflectance imaging showed enhanced intensity levels in long burned regions, which correlated with histology and distinguished between superficial and deep burns. This SWIR imaging method represents a novel, real‐time method to objectively distinguishing superficial from deep burns. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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