Urease inhibitory potential of extracts and active phytochemicals of Hypochaeris radicata (Asteraceae).
Urease inhibition potential of compound (1), guaiane-type sesquiterpene (2), confertin (3) and scopoletin (4) was carried out with high throughout mechanism-based assay. These compounds were isolated from Hypochaeris radicata L., an Asteraceae family member. The pure compounds were screened for thei...
| Publicado en: | Natural Product Research Vol. 34; no. 4; pp. 553 - 558 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Taylor & Francis Ltd
Feb2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142104212&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142104212 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14786419 RFT jtl: Natural Product Research issn: 14786419 maglogo: Y pubinfo: dt: Feb2020 vid: 34 iid: 4 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 142104212 10.1080/14786419.2018.1489387 142104212 ppf: 553 ppct: 5 formats: tig: atl: Urease inhibitory potential of extracts and active phytochemicals of Hypochaeris radicata (Asteraceae). aug: au: Abu-Izneid, Tareq Rauf, Abdur Saleem, Muhammad Mansour, Nashwa Abdelhady, Mohamed I. S. Ibrahim, Munjed M. Patel, Seema affil: Department of Chemistry, University of Swabi, Khyber Pakhtunkhwa, Pakistan sug: ab: Urease inhibition potential of compound (1), guaiane-type sesquiterpene (2), confertin (3) and scopoletin (4) was carried out with high throughout mechanism-based assay. These compounds were isolated from Hypochaeris radicata L., an Asteraceae family member. The pure compounds were screened for their urease and carbonic anhydrase inhibitory activities. The ethyl acetate fractions were subjected to column chromatography, which resulted in the isolation and purification of four compounds (1-4). On evaluation, compounds (1-4) exhibited selective activity against urease enzyme with an IC50 value of 180.11 ± 2.00, 27.18 ± 0.80, 24.12 ± 0.2 and 30.12 ± 1.10 mM respectively. The compounds (1-4) were found to be inactive against carbonic anhydrase enzyme. Thiourea was used as standard inhibitor (21 ± 0.14 mM) of urease pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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