Cryptococcus albidus Fungemia in an Immunosuppressed Child: Case Report and Systematic Literature Review.

Cryptococcus albidus , synonymous with Naganishia albida, rarely causes opportunistic infection in immunocompromised individuals. Its clinical features, particularly in children, are not well defined. Here, we report a case of C albidus fungemia in an immunosuppressed child; we also present results...

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Publicado en:Journal of the Pediatric Infectious Diseases Society Vol. 9; no. 1; pp. 100 - 106
Autores principales: Choe, Young June, Blatt, Daniel B, Yalcindag, Ali, Geffert, Sara F, Bobenchik, April M, Michelow, Ian C
Formato: case study research systematic review tables/charts Journal Article
Publicado: Oxford University Press / USA Mar2020
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Mar2020
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      pub: Oxford University Press / USA
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        atl: Cryptococcus albidus Fungemia in an Immunosuppressed Child: Case Report and Systematic Literature Review.
      aug:
        au:
          Choe, Young June
          Blatt, Daniel B
          Yalcindag, Ali
          Geffert, Sara F
          Bobenchik, April M
          Michelow, Ian C
        affil: Division of Infectious Diseases, Departments of Pediatrics, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence
      sug:
        subj:
          Cryptococcus
          Fungemia Diagnosis
          Immunocompromised Host In Infancy and Childhood
          Human
          PubMed
          Embase
          Opportunistic Infections
          Immunosuppression
          Central Nervous System Infections
          Fungemia Drug Therapy
          Child
          Antifungal Agents Therapeutic Use
          Systematic Review
          Child: 6-12 years
      ab: Cryptococcus albidus , synonymous with Naganishia albida, rarely causes opportunistic infection in immunocompromised individuals. Its clinical features, particularly in children, are not well defined. Here, we report a case of C albidus fungemia in an immunosuppressed child; we also present results of a systematic review, for which we searched PubMed, Embase, and Web of Science using the keywords "cryptococcus" and "albidus." Our goal was to describe the spectrum of disease, diagnostic approaches, therapies, and outcomes. We identified 20 cases of invasive infection, only 2 of which involved children, and 7 cases of noninvasive infection. The reports originated in the Americas, Europe, and Asia. Of those with invasive infection, 16 (80%) patients had an underlying chronic disorder or had received immunosuppressive therapy, 8 (40%) had fungemia, and 6 (30%) had a central nervous system infection. The attributable case fatality rate was 40%. C albidus is an opportunistic yeast that can rarely cause life-threatening fungemia and central nervous system infection in individuals of any age, especially those who are immunocompromised.
      pubtype: Academic Journal
      doctype:
        case study
        research
        systematic review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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