A nomogram to predict survival of patients with intermediate-stage hepatocellular carcinoma after transarterial chemoembolization combined with microwave ablation.
Objectives: To develop a prognostic nomogram based on the albumin-bilirubin (ALBI) grade for prediction of the long-term survival of patients with intermediate-stage hepatocellular carcinoma (HCC) after transarterial chemoembolization combined with microwave ablation (TACE-MWA).Methods: We retrospec...
| Published in: | European Radiology Vol. 30; no. 4; pp. 2377 - 2391 |
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| Main Authors: | , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Springer Nature
Apr2020
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142141847&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142141847 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Apr2020 vid: 30 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 142141847 142141847 NLM31900694 142141847 10.1007/s00330-019-06438-8 NLM31900694 142141847 ppf: 2377 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: A nomogram to predict survival of patients with intermediate-stage hepatocellular carcinoma after transarterial chemoembolization combined with microwave ablation. aug: au: Ni, Jia-yan Fang, Zhu-ting Sun, Hong-liang An, Chao Huang, Zhi-mei Zhang, Tian-qi Jiang, Xiong-ying Chen, Yao-ting Xu, Lin-feng Huang, Jin-hua affil: Department of Minimally Invasive Interventional Radiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Cancer for Cancer Medicine, 651 Dongfeng Road East, 510060, Guangzhou, Guangdong Province, People's Republic of China sug: subj: Neoplasm Staging Methods Carcinoma, Hepatocellular Therapy Liver Neoplasms Therapy Models, Statistical Microwaves Therapeutic Use Chemoembolization, Therapeutic Methods Magnetic Resonance Imaging Female Aged Adolescence Carcinoma, Hepatocellular Diagnosis Treatment Outcomes Retrospective Design Middle Age Young Adult Adult Human Tomography, X-Ray Computed Prognosis Male Liver Neoplasms Diagnosis Validation Studies Comparative Studies Evaluation Research Multicenter Studies Funding Source Aged: 65+ years Adolescent: 13-18 years Middle Aged: 45-64 years Adult: 19-44 years Female Male ab: Objectives: To develop a prognostic nomogram based on the albumin-bilirubin (ALBI) grade for prediction of the long-term survival of patients with intermediate-stage hepatocellular carcinoma (HCC) after transarterial chemoembolization combined with microwave ablation (TACE-MWA).Methods: We retrospectively studied 546 consecutive patients with intermediate-stage HCC according to the Barcelona Clinic Liver Cancer guidelines who underwent TACE-MWA between January 2000 and December 2016. Overall survival (OS) and progression-free survival (PFS) were analyzed. The predictive value of the ALBI grade was investigated. The prognostic nomogram was constructed using the independent predictors assessed by the multivariate Cox proportional hazards model.Results: After a median follow-up of 35.0 months (range, 4.0-221.0 months), 380 patients had died. The median OS was 35.0 months (95% confidence interval (CI), 30.84-39.16 months), and the median PFS was 6.5 months (95% CI, 6.13-6.87 months). The ALBI grade was validated as an independent predictor of OS (p < 0.001). Multivariate analyses showed that Eastern Cooperative Oncology Group performance status score more than 0, presence of liver cirrhosis, a-fetoprotein level above 400 ng/mL, tumor size greater than 5 cm, tumor number more than 3, advanced ALBI grade, and treatment sessions of TACE or MWA fewer than 3 were independently associated with overall mortality. The prognostic nomogram incorporating these eight predictors achieved good calibration and discriminatory abilities with a concordance index of 0.770 (95% CI, 0.746-0.795).Conclusions: The prognostic nomogram based on the ALBI grade resulted in reliable efficacy for prediction of individualized OS in patients with intermediate-stage HCC after TACE-MWA.Key Points: • TACE-MWA was associated with a median overall survival of 35.0 months for patients with intermediate-stage HCC. • A prognostic nomogram was built to predict individualized survival of patients with intermediate-stage HCC after TACE-MWA. • The prognostic nomogram incorporating eight predictors achieved good calibration and discriminatory abilities with a concordance index of 0.770. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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