Functional and metabolic imaging in transthoracic biopsies guided by computed tomography.
Objectives: CT-guided biopsy of indeterminate lung lesions sometimes provides insufficient histological results due to tumor necrosis. Functional and metabolic methods such as DWI-MR and PET-CT may help by directing sample collection to a lesion area of greater biological representativeness. The obj...
| Publicado en: | European Radiology Vol. 30; no. 4; pp. 2041 - 2049 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Apr2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142141898&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142141898 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Apr2020 vid: 30 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 142141898 142141898 NLM31900696 10.1007/s00330-019-06591-0 NLM31900696 142141898 ppf: 2041 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Functional and metabolic imaging in transthoracic biopsies guided by computed tomography. aug: au: Zurstrassen, Charles E. Tyng, Chiang J. Guimarães, Marcos D. Barbosa, Paula N. V. P. Pinto, Clovis A. L. Bitencourt, Almir G. V. Gross, Jeffersson L. Lima, Eduardo N. P. Cavalcante, Aline C. B. S. Matushita Junior, João P. K. Chojniak, Rubens affil: AC Camargo Cancer Center, R. Prof. Antônio Prudente, 211, 01509-010, São Paulo, BR, Brazil sug: subj: Magnetic Resonance Imaging Methods Lung Biopsy Methods Lung Neoplasms Diagnosis Cross Sectional Studies Fludeoxyglucose F 18 Pharmacodynamics Female Radiopharmaceuticals Pharmacodynamics Male Adult Prospective Studies Aged Middle Age Clinical Assessment Tools Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Objectives: CT-guided biopsy of indeterminate lung lesions sometimes provides insufficient histological results due to tumor necrosis. Functional and metabolic methods such as DWI-MR and PET-CT may help by directing sample collection to a lesion area of greater biological representativeness. The objective is to evaluate the histopathological results based on findings on ADC and SUV levels in lung lesions suspected for primary cancer.Methods: Tissue samples were evaluated after undergoing biopsies guided by either DWI-MR or PET-CT findings. In each patient, sample collection from two lesion areas was guided by local ADC and SUV. Values were used to define areas of low vs. high suspicion for cancer.Results: Patients who underwent DWI-MR had median lesion size of 78.0 mm. Areas of higher suspicion (HSA) had a median ADC of 1.1 × 10-3 mm2/s, while areas of lower suspicion (LSA) had median ADC of 1.8 × 10-3 mm2/s (p = 0.0001). All HSA samples and 71.43% of LSA samples were positive for cancer (p = 0.0184). Patients who performed PET-CT had median lesion size of 61.0 mm. Median SUV was 7.1 for HSA and 3.9 for LSA (p = 0.0002). Positivity for cancer was observed in 76.9% of samples for both HSA and LSA (p = 0.0522).Conclusion: Use of DWI-MR and PET-CT showed that tumors are functional and metabolically heterogeneous and that this heterogeneity has implications for histopathological diagnosis.Key Points: • Lung cancer is heterogeneous regarding functional and metabolic imaging. • Tumor heterogeneity may have implications in histopathological diagnosis. • Intralesional lower levels of ADC target highly suspected areas with a significant improvement in lung cancer diagnosis. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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