Fully Automated and Real-Time Volumetric Measurement of Infarct Core and Penumbra in Diffusion- and Perfusion-Weighted MRI of Patients with Hyper-Acute Stroke.
Multimodal magnetic resonance imaging (MRI) has emerged as a promising tool for diagnosing ischemic stroke and for determining treatment strategies in the acute phase. The detection and quantification of the penumbra and the infarct core regions aid the assessment of the potential risks and benefits...
| Publicado en: | Journal of Digital Imaging Vol. 33; no. 1; pp. 262 - 273 |
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| Autores principales: | , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142164508&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142164508 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08971889 DOQ jtl: Journal of Digital Imaging issn: 08971889 maglogo: N pubinfo: dt: Feb2020 vid: 33 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 142164508 142164508 142164508 10.1007/s10278-019-00222-2 142164508 ppf: 262 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Fully Automated and Real-Time Volumetric Measurement of Infarct Core and Penumbra in Diffusion- and Perfusion-Weighted MRI of Patients with Hyper-Acute Stroke. aug: au: Lee, Hyunna Jung, Kyesam Kang, Dong-Wha Kim, Namkug affil: Health Innovation Big Data Center, Asan Institute for Life Science, Asan Medical Center, 05505, Seoul, South Korea sug: subj: Magnetic Resonance Imaging Methods Stroke Diagnosis Ischemia Diagnosis Algorithms Utilization Stroke Patients Human Image Processing, Computer Assisted Descriptive Statistics Pearson's Correlation Coefficient ab: Multimodal magnetic resonance imaging (MRI) has emerged as a promising tool for diagnosing ischemic stroke and for determining treatment strategies in the acute phase. The detection and quantification of the penumbra and the infarct core regions aid the assessment of the potential risks and benefits of thrombolysis by providing information on salvageable tissue or ischemic lesion age. In this study, we proposed a fully automated and real-time algorithm to compute parameter maps of perfusion-weighted images (PWIs) and to identify an infarct core from diffusion-weighted images (DWIs). DWI and PWI were obtained using a 1.5 Tesla MRI scanner for 15 patients with acute ischemic stroke. Parameter maps of PWI were computed using restricted gamma-variate curve fitting and Fourier-based deconvolution. The ischemic penumbra was identified using time-to-maximum (Tmax) > 6 s as the mutual optimal threshold, while the infarct core was segmented using an adaptive thresholding on DWI. When the penumbra on PWI was compared with that generated using commercial software Pearson's linear correlation coefficient between penumbra volumes was 0.601 (p = 0.030), and the Dice coefficient was 0.51 ± 0.15. The infarct core on DWI was compared with the manually segmented gold standard. Dice coefficient between the manually drawn and automated segmented infarct cores was 0.62 ± 0.18. The processing times for PWI and DWI were 222.9 ± 16.4 and 53.4 ± 4.8 s, respectively. In conclusion, we demonstrate a fully automated and real-time algorithm to segment the penumbra and the infarct core regions based on PWI and DWI. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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