Clinical implications of multiple glioblastomas: An analysis of prognostic factors and survival to distinguish from their single counterparts.
Purpose: Glioblastoma (GBM) has the highest fatality rate among primary malignant brain tumors. GBMs with synchronous multiple foci (multiple GBMs) is rarely diagnosed in the clinical scenario. This study aims to compare the clinical characteristics between multiple and single GBMs and to identify f...
| Publicado en: | Journal of the Formosan Medical Association Vol. 119; no. 3; pp. 728 - 735 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Elsevier B.V.
Mar2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142165881&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142165881 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09296646 3O8P jtl: Journal of the Formosan Medical Association issn: 09296646 maglogo: N pubinfo: dt: Mar2020 vid: 119 iid: 3 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 142165881 142165881 NLM31515159 10.1016/j.jfma.2019.08.024 NLM31515159 142165881 ppf: 728 ppct: 7 formats: tig: atl: Clinical implications of multiple glioblastomas: An analysis of prognostic factors and survival to distinguish from their single counterparts. aug: au: Shieh, Li-Tsun Guo, How-Ran Chang, Yu-Kang Lu, Na-Mi Ho, Sheng-Yow affil: Department of Radiation Oncology, Chi-Mei Medical Center, Liouying, Tainan, Taiwan sug: subj: Brain Neoplasms Mortality Glioma Mortality Male Prognosis Young Adult Brain Neoplasms Therapy Retrospective Design Aged Glioma Therapy Taiwan Brain Neoplasms Radiotherapy Aged, 80 and Over Glioma Radiotherapy Brain Pathology Middle Age Survival Analysis Adult Female Arthritis Impact Measurement Scales Scales Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Adult: 19-44 years Male Female ab: Purpose: Glioblastoma (GBM) has the highest fatality rate among primary malignant brain tumors. GBMs with synchronous multiple foci (multiple GBMs) is rarely diagnosed in the clinical scenario. This study aims to compare the clinical characteristics between multiple and single GBMs and to identify factors associated with the survival of GBM and evaluate their effects.Methods: We retrospectively reviewed the medical records of patients with primary GBM in a referral medical center in Taiwan who were diagnosed between 2005 and 2016. They were identified from the cancer registry database of the center and followed from the date of diagnosis to october 2018. The primary endpoint of this study was overall survival (OS), and the independent factors for survival were identified through Cox regressions.Results: A total of 48 patients were identified, of whom 44 GBM (92%) and 4 gliosarcoma (GSM) (8%). Preoperative images showed five (10%) patients had multiple brain lesions. GSM showed a high ratio of multiple lesions (50%) than patients with GBM (5%) (p = 0.05). Those with multiple lesions had significantly worse median OS of 8.2 months compared to patients with a single lesion (16 months, p = 0.03). We found that multiple GBMs was a predictor of worse survival (hazard ratio [HR] = 3.57, 95% confidence interval [95%CI]: 1.26-10.13) after adjusting for other significant predictor of radiotherapy (HR = 0.47, 95%CI: 0.23-0.96).Conclusion: Patients with multiple GBMs had worse survival compared to those with single GBM. GBM patients without post-operative radiotherapy were also a predictor of worse survival. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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