Gut Microbiota Profile of Obese Diabetic Women Submitted to Roux-en-Y Gastric Bypass and Its Association with Food Intake and Postoperative Diabetes Remission.
Gut microbiota composition is influenced by environmental factors and has been shown to impact body metabolism. Objective: To assess the gut microbiota profile before and after Roux-en-Y gastric bypass (RYGB) and the correlation with food intake and postoperative type 2 diabetes remission (T2Dr). De...
| Publicado en: | Nutrients Vol. 12; no. 2; pp. 278 - 279 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
MDPI
Feb2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142180417&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142180417 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20726643 B0TT jtl: Nutrients issn: 20726643 maglogo: N pubinfo: dt: Feb2020 vid: 12 iid: 2 pid: 97109 pub: MDPI artinfo: ui: 142180417 142180417 142180417 10.3390/nu12020278 142180417 ppf: 278 ppct: 1 formats: tig: atl: Gut Microbiota Profile of Obese Diabetic Women Submitted to Roux-en-Y Gastric Bypass and Its Association with Food Intake and Postoperative Diabetes Remission. aug: au: Al Assal, Karina Prifti, Edi Belda, Eugeni Sala, Priscila Clément, Karine Dao, Maria-Carlota Doré, Joel Levenez, Florence Taddei, Carla R. Fonseca, Danielle Cristina Rocha, Ilanna Marques Balmant, Bianca Depieri Thomas, Andrew Maltez Santo, Marco A. Dias-Neto, Emmanuel Setubal, João Carlos Zucker, Jean-Daniel Belarmino, Giliane Torrinhas, Raquel Susana Waitzberg, Dan L. affil: Department of Gastroenterology, FMUSP, School of Medicine, University of São Paulo, Digestive Surgery Discipline (LIM 35), São Paulo 01246-903, Brazil sug: subj: Gut Microbiota Metabolism Obesity Therapy Women Diabetic Patients Anastomosis, Roux-en-Y Bariatric Surgery Food Intake Postoperative Period Diabetes Mellitus, Type 2 Disease Remission Human Genetic Profile Diet Records Gut Microbiota Physiology ab: Gut microbiota composition is influenced by environmental factors and has been shown to impact body metabolism. Objective: To assess the gut microbiota profile before and after Roux-en-Y gastric bypass (RYGB) and the correlation with food intake and postoperative type 2 diabetes remission (T2Dr). Design: Gut microbiota profile from obese diabetic women was evaluated before (n = 25) and 3 (n = 20) and 12 months (n = 14) after RYGB, using MiSeq Illumina-based V4 bacterial 16S rRNA gene profiling. Data on food intake (7-day record) and T2Dr (American Diabetes Association (ADA) criteria) were recorded. Results: Preoperatively, the abundance of five bacteria genera differed between patients with (57%) and without T2Dr (p < 0.050). Preoperative gut bacteria genus signature was able to predict the T2Dr status with 0.94 accuracy ROC curve (receiver operating characteristic curve). Postoperatively (vs. preoperative), the relative abundance of some gut bacteria genera changed, the gut microbial richness increased, and the Firmicutes to Bacteroidetes ratio (rFB) decreased (p < 0.05) regardless of T2Dr. Richness levels was correlated with dietary profile pre and postoperatively, mainly displaying positive and inverse correlations with fiber and lipid intakes, respectively (p < 0.05). Conclusions: Gut microbiota profile was influenced by RYGB and correlated with diet and T2Dr preoperatively, suggesting the possibility to assess its composition to predict postoperative T2Dr. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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