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Application of Acellular Tissue Matrix for Enhancement of Weak Abdominal Wall in Animal Model.

Background. Abdominal wall weakness occurs when the strength of muscle decreases due to physiological reason or iatrogenic injury. However, the treatment of this disease is complicated. Aim. To study the therapeutic effect of acellular tissue matrix (ACTM), compared with the polypropylene mesh. Meth...

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Published in:BioMed Research International pp. 1 - 11
Main Authors: Wang, Minggang, Yang, Shuo, Cao, Zhen, Hu, Sanyuan
Format: pictorial research tables/charts Journal Article
Published: Wiley-Blackwell 3/12/2020
Online Access:View this record in EBSCOhost
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        23146133
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      jtl: BioMed Research International
      issn: 23146133
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    pubinfo:
      dt: 3/12/2020
      pid: 480
      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        142252633
        142252633
        142252633
        10.1155/2020/3475289
        142252633
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      ppct: 10
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        atl: Application of Acellular Tissue Matrix for Enhancement of Weak Abdominal Wall in Animal Model.
      aug:
        au:
          Wang, Minggang
          Yang, Shuo
          Cao, Zhen
          Hu, Sanyuan
        affil: Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, China
      sug:
        subj:
          Tissue Scaffolds
          Polyenes
          Surgical Mesh
          Materials Testing
          Abdomen Pathology
          Abdomen Surgery
          Animal Studies
          Rabbits
          Motor Neurons Surgery
          Abdominal Muscles Surgery
          Histological Techniques
          Microscopy, Electron, Scanning
          Tensile Strength
          Stress, Mechanical
          Time Factors
      ab: Background. Abdominal wall weakness occurs when the strength of muscle decreases due to physiological reason or iatrogenic injury. However, the treatment of this disease is complicated. Aim. To study the therapeutic effect of acellular tissue matrix (ACTM), compared with the polypropylene mesh. Methods. An abdominal wall weakness model was established in rabbits through motor nerves cutting. The polypropylene mesh and ACTM were implanted in the left and right abdomen sides, respectively. Mechanical testing of abdominal wall muscle and histology and scanning electron microscopy (SEM) evaluation of abdominal tissue explants were performed. Results. In animal model establishment, the abdominal length of healthy and weakened abdominal wall was 17.0 ± 0.7 cm and 19.0 ± 1.2 cm, respectively (P = 0.022), and the weak abdominal wall group showed a significant decrease of 1.116 ± 0.221 MPa in tensile stress (P < 0.001) and 9.126 ± 2.073% in tensile strain (P < 0.001). In materials implantation experiment, compared with polypropylene group, ACTM group decreased 2.409 ± 0.806 MPa after 24 weeks (P < 0.001) and 2.319 ± 0.486 MPa after 48 weeks (P < 0.001) in tensile stress and increased 15.259% after 24 weeks (P < 0.001) and 15.845% after 48 weeks (P < 0.001) remarkably in tensile strain. Conclusion. The abdominal wall weakness model in rabbits was successfully established. ACTM is a promising biological material to be possibly further applied in clinical surgery in patients with abdominal wall weakness.
      pubtype: Academic Journal
      doctype:
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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