Utility and accuracy of transient elastography in determining liver fibrosis: a case-control study.
The objectives of this prospective case-control study were to determine liver stiffness (LSM) by transient elastography (TE) in children with newly diagnosed chronic liver disease (CLD) and to find out normal values in healthy Indian children. Two groups (A: 50 CLD who underwent liver biopsy and B:...
| Publicado en: | European Journal of Pediatrics Vol. 179; no. 4; pp. 671 - 678 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142315512&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142315512 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03406199 CR1 jtl: European Journal of Pediatrics issn: 03406199 maglogo: N pubinfo: dt: Apr2020 vid: 179 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 142315512 142315512 NLM31960149 142315512 10.1007/s00431-019-03561-y NLM31960149 142315512 ppf: 671 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Utility and accuracy of transient elastography in determining liver fibrosis: a case-control study. aug: au: Jain, Vikas Poddar, Ujjal Negi, Tajwar Singh Saraswat, Vivek A Krishnani, Narendra Yachha, Surender Kumar Srivastava, Anshu affil: Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, 226014, Lucknow, India sug: subj: Ultrasonography Standards Liver Cirrhosis Diagnosis Child Prospective Studies Male Case Control Studies Female Adolescence Liver Cirrhosis Physiopathology Sensitivity and Specificity Ultrasonography Methods Human Child: 6-12 years Adolescent: 13-18 years Male Female ab: The objectives of this prospective case-control study were to determine liver stiffness (LSM) by transient elastography (TE) in children with newly diagnosed chronic liver disease (CLD) and to find out normal values in healthy Indian children. Two groups (A: 50 CLD who underwent liver biopsy and B: 50 healthy) aged 5-18 years were recruited prospectively. Liver biopsies were scored as per Metavir scoring and compared with TE. The median age of 100 recruited children was 13.6 years. In group B, normal LSM was 4.9 (2.5-7.3) kPa with significantly higher LSM in adolescent males (5.6 (4.1-7.3) kPa) as compared with females (4.3 (3.7-4.9) kPa), p = 0.001. In group A, TE was excellent in discriminating significant fibrosis (≥ F2) (P = 0.001) at a cut-off value of 10.6 kPa with area under receiver operating characteristic curve of 0.96. Metavir fibrosis stage (β = 0.611; R2 = 0.586) and age (β = 0.230; R2 = 0.586) were independent variables associated with higher LSM in stepwise multiple logistic regression analysis.Conclusions: TE is an excellent non-invasive tool to assess significant liver fibrosis and can be used as an alternative to liver biopsy. Normative value of TE in adolescent males is higher than in females.What is Known:• Transient elastography is a good non-invasive test for liver fibrosis assessment.• Normal liver stiffness depends on race, gender, and age.What is New:• This is the first study from India to show the normative data of transient elastography in healthy Indian children.• We have documented that liver stiffness measurement by fibroscan in treatment naïve chronic liver disease has excellent correlation in significant fibrosis, severe fibrosis, and cirrhosis. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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