Renal cell tumors with an entrapped papillary component: a collision with predilection for oncocytic tumors.
Renal cell tumors with mixed morphology resembling multiple renal cell carcinoma (RCC) subtypes are generally regarded as unclassified RCC. However, occasionally, papillary adenoma or RCC appears admixed with a larger, different tumor histology. We retrieved 17 renal tumors containing a papillary ad...
| Publicado en: | Virchows Archiv: European Journal of Pathology Vol. 476; no. 3; pp. 399 - 408 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Mar2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142371338&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142371338 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09456317 O1Z jtl: Virchows Archiv: European Journal of Pathology issn: 09456317 maglogo: N pubinfo: dt: Mar2020 vid: 476 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 142371338 142371338 NLM31444626 10.1007/s00428-019-02648-z NLM31444626 142371338 ppf: 399 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Renal cell tumors with an entrapped papillary component: a collision with predilection for oncocytic tumors. aug: au: Williamson, Sean R. Cheng, Liang Gadde, Ramya Giannico, Giovanna A. Wasco, Matthew J. Taylor Smith, Paul J. Gupta, Nilesh S. Grignon, David J. Jorda, Merce Kryvenko, Oleksandr N. affil: Department of Pathology and Laboratory Medicine and Henry Ford Cancer Institute, Henry Ford Health System, Detroit, MI, USA sug: subj: Carcinoma, Renal Cell Pathology Neoplasms, Multiple Primary Pathology Adenoma Pathology Kidney Neoplasms Pathology Middle Age Male Aged Aged, 80 and Over Female Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Renal cell tumors with mixed morphology resembling multiple renal cell carcinoma (RCC) subtypes are generally regarded as unclassified RCC. However, occasionally, papillary adenoma or RCC appears admixed with a larger, different tumor histology. We retrieved 17 renal tumors containing a papillary adenoma or papillary RCC component admixed with another tumor histology and studied them with immunohistochemistry and fluorescence in situ hybridization (FISH). Larger tumors were oncocytomas (n = 10), chromophobe RCCs (n = 5), borderline oncocytic tumor (n = 1), and clear cell RCC (n = 1). The size of papillary component ranged from 1 to 34 mm. One tumor was an oncocytoma encircled by a cyst (2.0 cm) with papillary hyperplasia of the lining. The papillary lesions were diffusely cytokeratin 7 positive (17/17), in contrast to "host" tumors. Alpha-methylacyl-coA-racemase labeling was usually stronger in the papillary lesions (13/15). KIT was negative in all papillary lesions and the clear cell RCC and positive in 16/16 oncocytic or chromophobe tumors. Eight of 15 (53%) collision tumors had differing FISH results in the two components. A papillary renal cell proliferation within another tumor is an uncommon phenomenon with predilection for oncocytoma and chromophobe RCC, possibly related to their common entrapment of benign tubules. When supported by distinct morphology and immunohistochemistry in these two components, this phenomenon should be diagnosed as a collision of two processes. A diagnosis of unclassified RCC should be avoided, due to potential misrepresentation as an aggressive renal cancer. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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