Optimized Cylindrical Diffuser Powers for Interstitial PDT Breast Cancer Treatment Planning: A Simulation Study.
Purpose. It is well known that interstitial photodynamic therapy (iPDT) of large tumors requires effective planning to ensure efficient delivery of therapeutic dose to the target tumors. This should be achieved in parallel with minimal damage to the nearby intact tissues. To that end, clinical iPDT...
| Publicado en: | BioMed Research International pp. 1 - 12 |
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| Autores principales: | , , |
| Formato: | algorithm equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
3/23/2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142387506&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142387506 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 3/23/2020 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 142387506 142387506 142387506 10.1155/2020/2061509 142387506 ppf: 1 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Optimized Cylindrical Diffuser Powers for Interstitial PDT Breast Cancer Treatment Planning: A Simulation Study. aug: au: Ismael, Fatimah S. Amasha, Hani Bachir, Wesam affil: Biomedical Photonics Laboratory, Department of Laser Physics and Technology, Higher Institute for Laser Research and Applications, Damascus University, Syria sug: subj: Breast Neoplasms Therapy Photodynamic Therapy Methods Simulations Human Descriptive Statistics Dosage Forms Dosage Calculation ab: Purpose. It is well known that interstitial photodynamic therapy (iPDT) of large tumors requires effective planning to ensure efficient delivery of therapeutic dose to the target tumors. This should be achieved in parallel with minimal damage to the nearby intact tissues. To that end, clinical iPDT can be attained using cylindrical diffusing optical fibers (CDFs) as light sources. In this work, we optimize output CDF powers in order to deliver a prescribed light dose to a spherical volume such as a tumor node. Methods. Four CDFs are placed vertically inside the tumor node. The fluence rate is calculated using the diffusion equation. Therapeutic target dose is (20-50) J·cm-2. The optical properties ( μ a = 0.085 c m − 1 , μ s ′ = 16 c m − 1 ) of a breast tumor and the treatment time of 150 sec are used to calculate the fluence rate. Results. For four CDFs, the therapeutic target dose (20-50) J·cm-2 is delivered to more than 90%. This is the ratio of the total points that receive the target dose in proportion to the total points in the volume of the node of 3 cm in diameter, whereas, in larger nodes, the ratio is decreased to approximately 67%. Five CDFs are required to improve this ratio by more than 10%. Conclusion. Optimizing delivered powers enables the distribution of the therapeutic dose uniformly in the medium. In addition, this simulation study represents an essential part of a development dosimetry system for measuring and controlling the optical dose in the breast tumors. pubtype: Academic Journal doctype: algorithm equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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