Augmentation index, a predictor of cardiovascular events, is increased in children and adolescents with primary nephrotic syndrome.
Background: Arterial stiffness is associated with an increased risk of cardiovascular diseases. Augmentation index (AIx@75), a measure of arterial stiffness and wave reflection, has not been evaluated in patients with primary nephrotic syndrome (PNS). We investigated whether central and peripheral v...
| Publicado en: | Pediatric Nephrology Vol. 35; no. 5; pp. 815 - 828 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
May2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142407953&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142407953 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: May2020 vid: 35 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 142407953 142407953 142407953 10.1007/s00467-019-04434-0 142407953 ppf: 815 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Augmentation index, a predictor of cardiovascular events, is increased in children and adolescents with primary nephrotic syndrome. aug: au: Alves, Cláudia Pinho, José Felippe dos Santos, Luzia Maria Magalhães, Giselle da Silva, Júnia Maria Fontes, Fernanda Luiza Caligiorne, Sordaini Maria Pinheiro, Sérgio Rodrigues-Machado, Maria Glória affil: Medical Sciences Faculty of Minas Gerais, Post-Graduation Program in Health Sciences, Belo Horizonte, MG, Brazil sug: subj: Arterial Stiffness Evaluation Cardiovascular Risk Factors Nephrotic Syndrome Complications Human Descriptive Statistics Hemodynamics Nonexperimental Studies Child Adolescence Blood Pressure Child: 6-12 years Adolescent: 13-18 years ab: Background: Arterial stiffness is associated with an increased risk of cardiovascular diseases. Augmentation index (AIx@75), a measure of arterial stiffness and wave reflection, has not been evaluated in patients with primary nephrotic syndrome (PNS). We investigated whether central and peripheral vascular profiles, hemodynamic parameters, and biochemical tests are associated with AIx@75 in PNS patients. Methods: This observational study involved 38 children and adolescents with PNS (12.14 ± 3.65 years) and 37 healthy controls (13.28 ± 2.80 years). Arterial stiffness and vascular and hemodynamic parameters were measured noninvasively using the Mobil-O-Graph® (IEM, Stolberg, Germany). In the PNS group, biochemical tests and corticosteroid dosage/treatment time were analyzed. Results: Peripheral and central systolic blood pressure (SBPp, SBPc) Z-scores were significantly higher in the PNS patients. AIx@75 was significantly higher in the PNS patients (25.14 ± 9.93%) than in controls (20.84 ± 7.18%). In the control group, AIx@75 negatively correlated with weight (r = − 0.369; p = 0.025), height (r = − 0.370; p = 0.024), and systolic volume/body surface (r = − 0.448; p = 0.006). In the PNS group, a univariate linear correlation showed that AIx@75 negatively correlated with weight (r = − 0.360; p = 0.027), height (r = 0.381; p = 0.18), and systolic volume/body surface (r = − 0.447; p < 0.002) and positively with the Z-score of SBPp (r = 0.407; p = 0.011), peripheral diastolic blood pressure (DBPp, r = 0.452; p = 0.004), SBPc (r = 0.416; p = 0.009), DBPc (r = 0.407; p = 0.011), triglycerides (r = 0.525; p = 0.001), and cholesterol [total (r = 0.539; p < 0.001), LDLc (r = 0.420; p = 0.010), and non-HDLc (r = 0.511; p = 0.001)]. Conclusions: Early abnormalities of AIx@75 and vascular parameters suggest that patients with PNS, even in stable condition, present subclinical indicators for the development of cardiovascular disease. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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