Maternal and perinatal characteristics, congenital malformations and the risk of wilms tumor: the ESTELLE study.
Purpose: Wilms tumor (WT), or nephroblastoma, is an embryonic tumor that constitutes the most common renal tumor in children. Little is known about the etiology of WT. The aim of this study was to investigate whether maternal or perinatal characteristics were associated with the risk of WT.Methods:...
| Published in: | Cancer Causes & Control Vol. 31; no. 5; pp. 491 - 502 |
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| Main Authors: | , , , , , , , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Springer Nature
May2020
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142472561&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142472561 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09575243 ODX jtl: Cancer Causes & Control issn: 09575243 maglogo: N pubinfo: dt: May2020 vid: 31 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 142472561 142472561 NLM32144681 142472561 10.1007/s10552-020-01288-y NLM32144681 142472561 ppf: 491 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Maternal and perinatal characteristics, congenital malformations and the risk of wilms tumor: the ESTELLE study. aug: au: Bauer, Hélène Rios, Paula Schleiermacher, Gudrun Valteau-Couanet, Dominique Bertozzi, Anne-Isabelle Thebaud, Estelle Gandemer, Virginie Pellier, Isabelle Verschuur, Arnauld Spiegel, Alexandra Notz-Carrere, Anne Bergeron, Christophe Orsi, Laurent Lacour, Brigitte Clavel, Jacqueline affil: CRESS, UMR1153, INSERM, Université de Paris, Villejuif, France sug: subj: Kidney Neoplasms Pathology Wilms' Tumor Pathology Adult Mothers Male Female Pregnancy Child Risk Factors Case Control Studies France Infant Infant, Newborn Birth Weight Young Adult Child, Preschool Human Funding Source Adult: 19-44 years Child: 6-12 years Infant: 1-23 months Infant, Newborn: birth-1 month Child, Preschool: 2-5 years Male Female ab: Purpose: Wilms tumor (WT), or nephroblastoma, is an embryonic tumor that constitutes the most common renal tumor in children. Little is known about the etiology of WT. The aim of this study was to investigate whether maternal or perinatal characteristics were associated with the risk of WT.Methods: The ESTELLE study is a national-based case-control study that included 117 cases of WT and 1,100 controls younger than 11 years old. The cases were children diagnosed in France in 2010-2011 and the controls were frequency matched with cases by age and gender. The mothers of case and control children responded to a telephone questionnaire addressing sociodemographic and perinatal characteristics, childhood environment, and lifestyle. Unconditional logistic regression models adjusted on potential cofounders were used to estimate the odds ratios (OR) and their confidence intervals (95% CI).Results: High birth weight and the presence of congenital malformation were associated with WT (OR 1.9 [95% CI 1.0-3.7] and OR 2.5 [95% CI 1.1-5.8], respectively). No association with breastfeeding or folic acid supplementation was observed.Conclusions: Although potential recall bias cannot be excluded, our findings reinforce the hypothesis that high birth weight and the presence of congenital malformation may be associated with an increased risk of WT. Further investigations are needed to further elucidate the possible role of maternal characteristics in the etiology of WT. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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