Altered nutritional status, inflammation and systemic vulnerability in patients with acute myocardial infarction undergoing percutaneous coronary revascularisation: A prospective study in a level 3 cardiac critical care unit.
Aim: The aim of the present study was to assess the influence of nutritional status, as expressed by Controlling Nutritional Status (CONUT) and Geriatric Nutritional Risk Index (GNRI) scores, on the inflammatory response following acute myocardial infarction (AMI) and the impact of an altered nutrit...
| Publicado en: | Nutrition & Dietetics Vol. 77; no. 2; pp. 212 - 223 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Apr2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142522450&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142522450 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14466368 QMK jtl: Nutrition & Dietetics issn: 14466368 maglogo: Y pubinfo: dt: Apr2020 vid: 77 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 142522450 142522450 145802738 142522450 10.1111/1747-0080.12536 142522450 ppf: 212 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Altered nutritional status, inflammation and systemic vulnerability in patients with acute myocardial infarction undergoing percutaneous coronary revascularisation: A prospective study in a level 3 cardiac critical care unit. aug: au: Rus, Victoria A. Chitu, Monica Cernea, Simona Benedek, Imre Hodas, Roxana Zavate, Ramona Nyulas, Tiberiu Hintea, Marian Benedek, Theodora affil: Communitary Nutrition and Food Hygiene Department, University of Medicine and Pharmacy, Tirgu Mures, Romania sug: subj: Myocardial Infarction Romania Cardiac Patients Nutritional Status Inflammation Vulnerability Percutaneous Coronary Intervention Myocardial Revascularization Surgical Patients Human Funding Source Prospective Studies Critical Care Scales Clinical Assessment Tools Nonexperimental Studies C-Reactive Protein Correlational Studies Malnutrition Length of Stay Outcomes (Health Care) Romania Nonrandomized Trials T-Tests Mann-Whitney U Test Fisher's Exact Test Comparative Studies Male Female Middle Age Aged Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Aim: The aim of the present study was to assess the influence of nutritional status, as expressed by Controlling Nutritional Status (CONUT) and Geriatric Nutritional Risk Index (GNRI) scores, on the inflammatory response following acute myocardial infarction (AMI) and the impact of an altered nutritional status and increased systemic inflammation on immediate evolution following AMI. Methods: This was an observational prospective study in which we used the CONUT score and GNRI on 86 consecutive patients with AMI receiving primary revascularisation, divided into a well‐nourished group (CONUT score 0–2, n = 68) and moderate‐to‐severe nutritional deficit group (CONUT score ≥ 3, n = 18). Inflammatory status was assessed on the basis of highly sensitive C‐reactive protein (hs‐CRP) at baseline and on day 5. Results: Malnourished patients presented significantly higher levels of serum hs‐CRP at baseline (33.6 ± 35.02 mg/dL vs 10.26 ± 25.93 mg/dL, P < 0.0001) and day 5 (52.8 ± 46.25 mg/dL vs 17.04 ± 24.78 mg/dL, P < 0.0001). GNRI values showed a weak but significant correlation with serum hs‐CRP at baseline (r = −0.26, P = 0.01) and day 5 (r = −0.44, P < 0.0001). Patients with altered nutritional status presented more frequent deterioration of their haemodynamical status, requiring inotropic support (P = 0.002) and longer hospitalisation in the acute cardiac care unit (4.27 ± 2.60 vs 2.85 ± 0.73 days, P = 0.005). Patients requiring intravenous inotropics had a higher CONUT score (2.31 ± 1.7 vs 1.17 ± 1.27, P = 0.01), lower GNRI (102.0 ± 5.31 vs 98.56 ± 5.2, P = 0.02) and higher hs‐CRP levels at baseline and day 5 (31.40 ± 46.57 vs 18.52 ± 32.98, P = 0.04 and 46.04 ± 51.50 vs 19.60 ± 46.05, P = 0.006). Conclusions: Malnourished patients with AMI had more expressed inflammation, increased blood vulnerability and worse outcomes. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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